建议进行术前运动训练以改善肺癌（LC）手术后的临床结果。然而，其预防术后生活质量（QoL）下降的有效性仍不清楚。本研究调查了术前家庭运动训练 (PHET) 对 LC 手术后生活质量的影响。等待 LC 切除的患者被随机分为 PHET 组或对照组 (CG)。 PHET 计划结合了有氧运动和抗阻运动，并每周进行电话监督。主要结局是通过欧洲癌症研究与治疗组织 (EORTC) 生活质量问卷 C30 (QLQ-C30) 在基线、手术前和手术后 1 个月进行 QoL 评估。次要结果是住院时间和身体表现。主要分析包括因子重复测量方差分析。此外，还评估了从基线到手术后出现临床恶化的患者比例。该研究纳入了意向治疗分析中的 41 名患者（68.1±9.3 岁；68.3% 男性）（20 名 PHET 患者，21 名 CG 患者） 。观察到整体 QoL 存在显着的组 × 时间交互作用 (p = 0.004)。总体生活质量的组间差异在术前（平均差 [MD]，13.5 分；95% 置信区间 [CI]，2.4-24.6；p = 0.019）和术后（MD，12.4 分；95）具有统计学意义和临床显着性。 % CI，1.3-23.4；p = 0.029），有利于 PHET。 71.4% 的 CG 患者报告总体生活质量临床恶化，而 PHET 患者的这一比例为 30% (p = 0.003)。在疼痛和食欲不振以及术后身体、情绪和角色功能方面发现有利于 PHET 的组间差异（p < 0.05）。与CG相比，PHET在改善术前五次坐站和术后运动能力方面优于CG（p<0.05）。没有观察到其他次要结局的组间差异。研究表明 PHET 可以有效预防 LC 手术后生活质量的下降。© 2023。作者。

Preoperative exercise training is recommended for improvement of clinical outcomes after lung cancer (LC) surgery. However, its effectiveness in preventing postoperative decline in quality of life (QoL) remains unknown. This study investigated the effect of preoperative home-based exercise training (PHET) on QoL after LC surgery.Patients awaiting LC resection were randomized to PHET or a control group (CG). The PHET program combined aerobic and resistance exercise, with weekly telephone supervision. Primary outcome was QoL-assessed with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 (QLQ-C30) at baseline, before surgery, and 1 month after surgery. The secondary outcomes were hospital length of stay and physical performance. The main analysis included a factorial repeated-measures analysis of variance. Additionally, the proportion of patients experiencing clinical deterioration from baseline to post-surgery was assessed.The study included 41 patients (68.1 ± 9.3 years; 68.3% male) in the intention-to-treat analysis (20 PHET patients, 21 CG patients). A significant group × time interaction was observed for global QoL (p = 0.004). Between-group differences in global QoL were statistically and clinically significant before surgery (mean difference [MD], 13.5 points; 95% confidence interval [CI], 2.4-24.6; p = 0.019) and after surgery (MD, 12.4 points; 95% CI, 1.3-23.4; p = 0.029), favoring PHET. Clinical deterioration of global QoL was reported by 71.4% of the CG patients compared with 30 % of the PHET patients (p = 0.003). Between-group differences in favor of PHET were found in pain and appetite loss as well as in physical, emotional and role functions after surgery (p < 0.05). Compared with CG, PHET was superior in improving preoperative five-times sit-to-stand and postoperative exercise capacity (p < 0.05). No between-group differences in other secondary outcomes were observed.The study showed that PHET can effectively prevent the decline in QoL after LC surgery.© 2023. The Author(s).