天然化合物，如类胡萝卜素、类黄酮、花青素或萜类化合物，是植物（色素）中发现的生理活性成分，通常称为植物化学物质或植物营养素。评估了生物补骨脂二氢黄酮、补骨脂二氢黄酮、青蒿素 C 和芳香树素化合物对 SW48、SNU-C1、COLO 205、RKO、LS411N 和 SW1417 癌细胞系的体外细胞毒性和抗结肠癌作用。酶和抗菌、抗真菌的结果都在微摩尔水平，具有良好的影响。这些天然化合物可能是药物设计的抗糖尿病、抗癌和抗菌候选药物。 α-淀粉酶和 α-葡萄糖苷酶的 IC50 结果分别为 14-19 和 5-119 µM。两种酶均检测到良好的抑制剂 Bavachinin（α-淀粉酶的 IC50：14.37μM，α-葡萄糖苷酶的 IC50：5.27μM）。通过分子对接研究评估了芳香树素、阿替匹林 C、补骨脂二氢黄酮和补骨脂二氢黄酮素对胰腺 α-淀粉酶和 α-葡萄糖苷酶的化学活性。使用分子对接研究了芳香树素、青蒿素 C、补骨脂二氢黄酮和补骨脂二氢黄酮素对上述细胞系中一些表达的表面受体蛋白（CD44、CD47、CXCR4、EGFR、叶酸受体、HER2 和内皮素受体）的化学活性。计算。结果说明了原子级特性和潜在的相互作用。根据对接分数，这些化学物质对酶和蛋白质具有很高的结合亲和力。此外，这些化合物与酶和受体形成了牢固的接触。因此，这些化合物可能是酶和癌细胞的潜在抑制剂。© 2023 Wiley periodicals LLC。

Natural compounds, such as carotenoids, flavonoids, anthocyanins, or terpenoids, are physiologically active components found in plants (pigments), often known as phytochemicals or phytonutrients. The in vitro cytotoxic and anticolon cancer effects of biologically bavachin, bavachinin, artepillin C, and aromadendrin compounds against SW48, SNU-C1, COLO 205, RKO, LS411N, and SW1417 cancer cell lines were assessed. Results of enzymes and antibacterial, antifungal were in level of micromolar that is good impacts. These natural compounds may be antidiabetic, anticancer, and antibacterial candidates for drug design. IC50 results were obtained between 14-19 and 5-119 µM for α-amylase and α-glucosidase, respectively. Good inhibitor Bavachinin was detected for both enzymes (IC50 for α-amylase: 14.37 µM and IC50 for α-glucosidase: 5.27 µM). The chemical activities of aromadendrin, artepillin C, bavachin, and bavachinin against pancreatic α-amylase and α-glucosidase were assessed by conducting the molecular docking study. The chemical activities of aromadendrin, artepillin C, bavachin, and bavachinin against some of the expressed surface receptor proteins (CD44, CD47, CXCR4, EGFR, folate receptor, HER2, and endothelin receptor) in the mentioned cell lines were investigated using the molecular docking calculations. The results illustrated the atomic-level properties and potential interactions. These chemicals have high binding affinities to the enzymes and proteins, according to the docking scores. In addition, the compounds formed strong contacts with the enzymes and receptors. Thus, these compounds could be potential inhibitors for enzymes and cancer cells.© 2023 Wiley Periodicals LLC.