纳米载体系统已应用于食管癌（EC）等疾病的研究，在改善传统制剂的非靶向性、非特异性毒性方面具有显着优势。一些化疗药物和高原子序数纳米材料对电离辐射有增敏作用，可作为放化疗增敏剂。金纳米粒子经牛血清白蛋白（BSA）和叶酸（FA）修饰，并核载紫杉醇（PTX）和姜黄素（CUR）。通过透射电子显微镜、傅里叶变换红外光谱和 Malvern Zetasizer 评估了 FA-BSA-Au@PTX/CUR 纳米药物的基本特性。通过紫外-可见分光光度法（UV-Vis）监测药物的封装和释放。通过细胞活力、集落形成、细胞凋亡、细胞周期分布、γ-H2AX分析实验观察FA-BSA-Au@PTX/CUR的生物毒性和放疗增敏作用。制备的纳米药物表现出良好的稳定性和球形形态。细胞摄取和细胞活力检测结果表明，FA-BSA-Au@PTX/CUR能够特异性靶向EC细胞KYSE150，并对增殖产生一定的抑制作用，对健康细胞Het-1A无明显毒性。此外，集落形成实验、细胞凋亡检测、细胞周期分布以及γ-H2AX分析结果表明，与单独使用X射线相比，FA-BSA-Au@PTX/CUR联合X射线表现出相对更强的效果。 FA-BSA-Au@PTX/CUR可以靶向EC癌细胞，作为安全有效的放疗增敏剂，提高EC的放疗效果。

Nanocarrier systems have been used in the study of esophageal cancer (EC) and other diseases, with significant advantages in improving the non-targeted and non-specific toxicity of traditional formulations. Some chemotherapeutic drugs and high atomic number nanomaterials have sensitization effects on ionizing radiation and can be used as chemoradiation sensitizers.Aurum (Au) nanoparticles were modified by bovine serum albumin (BSA) and folic acid (FA), and were core-loaded with paclitaxel (PTX) and curcumin (CUR). The basic characteristics of FA-BSA-Au@PTX/CUR nanomedicines were evaluated by transmission electron microscopy, Fourier transform infrared spectroscopy, and Malvern Zetasizer. The encapsulation and release of drugs were monitored by ultraviolet-visible spectrophotometry (UV-Vis). The biological toxicity and radiotherapy sensitization effect of FA-BSA-Au@PTX/CUR were observed by cell viability, colony formation, cell apoptosis, cell cycle distribution, and γ-H2AX analysis experiments.The prepared nanomedicines showed good stability and spherical morphology. The results of cell uptake and cell viability detection revealed that FA-BSA-Au@PTX/CUR could specifically target EC cell KYSE150 and exert a certain inhibitory effect on proliferation, with no obvious toxicity on healthy cells Het-1A. In addition, the results of the colony formation experiment, cell apoptosis detection, cell cycle distribution, and γ-H2AX analysis showed that compared with X-rays alone, FA-BSA-Au@PTX/CUR combined with X-rays exhibited relatively stronger radiotherapy sensitization and anti-tumor activity.FA-BSA-Au@PTX/CUR could target EC cancer cells and act as a safe and effective radiotherapy sensitizer to improve the radiotherapy efficacy of EC.