近年来，光热治疗金属纳米材料与多糖偶联形成的纳米颗粒作为修饰载体在肝癌靶向治疗中的应用受到广泛关注。在本工作中，从射干 (Belamcanda chinensis (L.) DC) 中获得了一种未描述的均质多糖 BCP50-2。结构分析表明，BCP50-2含有半乳糖和少量阿拉伯糖，主要由六个单糖残基组成：→3,5)-α-l-Araf-(1→,→4)-β-d- Galp-(1→, →4,6)-β-d-Galp-(1→, →3)-α-l-Galp-(1→, 末端 α-l-Araf, 末端 β-d-Galp为了增强BCP50-2的抗肿瘤活性，将BCP50-2与金纳米棒偶联制备了BCP50-2-AuNRs，用于治疗肝癌。BCP50-2-AuNRs呈棒状，长径为26.8nm，具有良好的光热转换效应，在近红外光照射下，BCP50-2-AuNRs具有光热效应，可抑制HepG2、A549和MCF-7细胞的生长，此外，BCP50-2-AuNRs还可抑制肝癌的发展通过诱导细胞凋亡、细胞周期停滞在 G2/M 期并抑制细胞迁移。此外，BCP50-2-AuNRs 抑制斑马鱼的肿瘤增殖、迁移和血管生成。总之，BCP50-2-AuNRs 可能在以下方面具有潜在用途：癌症治疗。版权所有 © 2023。由 Elsevier B.V. 出版。

In recent years, the application of the nanoparticles formed by coupling the metal nanomaterials of photothermal therapy with polysaccharides as the modified carrier in the targeted treatment of liver cancer has attracted extensive attention. In the present work, an undescribed homogeneous polysaccharide BCP50-2 was obtained from Belamcanda chinensis (L.) DC. The structural analysis displayed that BCP50-2 contained galactose and a small amount of arabinose, and was mainly composed of six monosaccharide residues: →3,5)-α-l-Araf-(1→, →4)-β-d-Galp-(1→, →4,6)-β-d-Galp-(1→, →3)-α-l-Galp-(1→, terminal α-l-Araf, and terminal β-d-Galp. To enhance the antitumor activity of BCP50-2, BCP50-2-AuNRs were prepared by coupling BCP50-2 with gold nanorods for the treatment of liver cancer. BCP50-2-AuNRs were rod-shaped with a long diameter of 26.8 nm and had good photothermal conversion effects. Under near-infrared light irradiation, BCP50-2-AuNRs possessed photothermal effects and suppressed the growth of HepG2, A549, and MCF-7 cells. In addition, BCP50-2-AuNRs inhibited the development of liver cancer by inducing cell apoptosis, cell cycle arrest in G2/M phases, and inhibiting cell migration. Moreover, BCP50-2-AuNRs inhibited tumor proliferation, migration, and angiogenesis in zebrafish. In summary, BCP50-2-AuNRs may be potentially useful for cancer treatment.Copyright © 2023. Published by Elsevier B.V.