代谢编程和重编程已成为改变免疫细胞功能的关键机制。因此，免疫代谢已成为治疗免疫介导疾病的一个有吸引力的目标领域。尽管如此，传递代谢线索的许多障碍仍然存在。在这篇综述中，我们考虑生物材料如何通过代谢配置的综合控制来改变免疫细胞代谢的操作，从而影响自身免疫、再生、移植和癌症的结果。我们强调纳米粒子和其他生物材料的特性，这些特性允许将代谢信号传递到免疫细胞的细胞内区室，或改变细胞外空间信号的策略。然后，我们提供了关于材料本身的物理特性对免疫代谢相互调节的潜力的观点。最后，强调了临床转化的机会。这次讨论有助于我们理解免疫代谢、基于生物材料的改变免疫细胞代谢结构的策略，以及这个不断发展的领域中的新兴概念。版权所有 © 2023 Elsevier B.V. 保留所有权利。

Metabolic programming and reprogramming have emerged as pivotal mechanisms for altering immune cell function. Thus, immunometabolism has become an attractive target area for treatment of immune-mediated disorders. Nonetheless, many hurdles to delivering metabolic cues persist. In this review, we consider how biomaterials are poised to transform manipulation of immune cell metabolism through integrated control of metabolic configurations to affect outcomes in autoimmunity, regeneration, transplant, and cancer. We emphasize the features of nanoparticles and other biomaterials that permit delivery of metabolic cues to the intracellular compartment of immune cells, or strategies for altering signals in the extracellular space. We then provide perspectives on the potential for reciprocal regulation of immunometabolism by the physical properties of materials themselves. Lastly, opportunities for clinical translation are highlighted. This discussion contributes to our understanding of immunometabolism, biomaterials-based strategies for altering metabolic configurations in immune cells, and emerging concepts in this evolving field.Copyright © 2023 Elsevier B.V. All rights reserved.