评估定期随访口腔白斑 (OL) 是否能够及早发现恶变 (MT)。 222 名连续 OL 患者（147 名女性，75 名男性）；中位随访期为 64 个月（范围：12-300）。分为三组：A组（n = 92）在医院随访； B组（n = 84）由牙医跟进； C 组 (n = 46) 失访。B 组中的 OL 与 A 组相比，尺寸更小 (<2 cm; p < 0.001)，显示出更多的角化过度 (p < 0.001) 和较少的中度/重度发育不良（p < 0.001）。 45 例 (20%) 患者发生 MT：A 组 32 例 (35%)，B 组 5 例 (6%)，C 组 8 例 (17%)。A 组之间临床肿瘤大小无显着差异。中位数：15 mm，范围：1-40）和 B 组（中位数：10 mm，范围：3-25；p = 0.496）。与 C 组（中位值：33mm，范围：3-100；p = 0.003）相比，A 组和 B 组患者的肿瘤尺寸较小（中位值：10mm，范围 1-40）。所有患者的肿瘤大小与末次就诊间隔呈正相关（p = 0.022）。定期随访 OL 有助于早期发现 MT。如果选择得当，由牙医进行 OL 随访似乎是可行的。© 2023 作者。 《口腔疾病》由 Wiley periodicals LLC 出版。

Evaluate whether regular follow-up of oral leukoplakia (OL) resulted in early detection of malignant transformation (MT).Two hundred and twenty-two consecutive patients with OL (147 females, 75 males); median follow-up period of 64 months (range: 12-300). Three groups were distinguished: group A (n = 92) follow-up at the hospital; group B (n = 84) follow-up by their dentist; group C (n = 46) lost to follow-up.OLs in group B compared to group A, were smaller in size (<2 cm; p < 0.001), showed more hyperkeratosis (p < 0.001) and less moderate/severe dysplasia (p < 0.001). MT occurred in 45 (20%) patients: 32 (35%) in group A, five (6%) in group B and eight (17%) in group C. There was no significant difference in clinical tumour size between group A (median: 15 mm, range: 1-40) and group B (median: 10 mm, range: 3-25; p = 0.496). Tumour size was smaller for patients in groups A and B (median: 10 mm, range 1-40) compared to group C (median: 33 mm, range: 3-100; p = 0.003). There was a positive correlation between tumour size and interval between the last visit in all patients (p = 0.022).Regular follow-up of OL resulted in early detection of MT. If properly selected, follow-up of OL performed by the dentist seems feasible.© 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.