背景随着氧化铜纳米颗粒（CuONP）在各个领域的工业应用不断增长，人们对其对环境、人类和动物健康的潜在有害后果的担忧也在增加。吉洛伊被认为是治疗各种疾病的替代药物。吉洛伊在帮助控制糖尿病、减轻关节炎和关节疼痛以及解决湿疹和痤疮等皮肤疾病方面的潜力凸显了其在传统医学中的多方面作用。此外，它被认为有益于减轻压力和焦虑水平，促进肝脏健康，并可能通过调节胆固醇水平影响心脏健康。新兴研究还探索了其在癌症预防方面的潜力。本研究旨在评估 CuONPs 的血液毒性和吉洛伊对成年大鼠的缓解作用。材料与方法本实验采用实验大鼠28只，分为4组（7只/组），如下：对照组不予任何剂量； CuONPs 组以 300 mg/kg/天的剂量施用氧化铜纳米颗粒； CuONPs 吉洛伊组以 300 mg/kg/天的剂量给予 CuONPs 加 100 mg/kg/天的吉洛伊；吉洛伊组仅用吉洛伊 100 mg/kg/天治疗。所有治疗均通过胃管饲进行，并连续不间断地持续28天。结果给动物服用 CuONP 会导致所检查的血液特征发生显着的不利变化。相反，当动物与吉洛伊共同给药时，观察到受干扰的血液水平得到恢复。结论 高剂量的氧化铜纳米粒子对实验室大鼠具有显着的血液毒性，补充 giloy 可以降低这种血液毒性。版权所有 © 2023，Ghareeb 等人。

Background In line with the growing industrial applications of copper oxide nanoparticles (CuONPs) in various fields, concerns about their potentially harmful consequences on the environment, human, and animal health are increasing. Giloy is considered an alternative medicine to treat various ailments. Giloy's potential in helping manage diabetes, alleviating arthritis and joint pain, and addressing skin disorders such as eczema and acne underscores its multifaceted role in traditional medicine. Moreover, it is deemed beneficial for reducing stress and anxiety levels, promoting liver health, and potentially impacting heart health by regulating cholesterol levels. Emerging research also explores its potential in cancer prevention. This study aimed to evaluate the hematotoxicity of CuONPs and the alleviating effect of giloy in adult rats. Materials and methods In this experiment, 28 laboratory rats were used, set to four groups (7/group), as follows: control group without any dose; CuONPs group administered copper oxide nanoparticles at 300 mg/kg/day; CuONPs + giloy group dosed with CuONPs at 300 mg/kg/day plus giloy at 100 mg/kg/day; giloy group treated only with giloy at 100 mg/kg/day. All treatments were given by gastric gavage and continued for 28 uninterrupted days. Results Dosing animals with CuONPs led to significant adverse changes in the examined blood profile. In contrast, when the animals were coadministered with giloy, restoring the disturbed blood levels was observed. Conclusion Copper oxide nanoparticles at a high dose had notable hematotoxicity in laboratory rats and, supplemented with giloy, could reduce this hematological toxicity.Copyright © 2023, Ghareeb et al.