多形性胶质母细胞瘤，通常称为 GBM 或胶质母细胞瘤，是一种 IV 级星形细胞瘤。脑肿瘤难以治疗，导致患者预后和生存不良。胶质瘤分为四个不同级别，其中GBM是最差级别的原发性脑肿瘤，生存期不到一年。脑肿瘤的基因组异质性导致诊断为胶质母细胞瘤的患者具有不同的特征。精准医学专注于这种特定的肿瘤类型，并提出专门的治疗方案，以实现更好的预后和总体生存（OS）。随着全基因组研究（GWS）的最新进展以及基于遗传、转录组、蛋白质组、表观遗传学的脑肿瘤的各种特征，和代谢组学，这篇综述讨论了基于胶质母细胞瘤不同特征的精准医学疗法、药物和诊断方法的进展和机遇。这篇综述详尽地调查了来自各种文献数据库的几篇作品。很明显，大多数原发性脑肿瘤包括胶质母细胞瘤，需要特异性和精准的治疗才能获得更好的预后和 OS。现在和将来，分子理解和发现特定疗法对于神经肿瘤学领域的治疗至关重要。© 作者。

Glioblastoma multiforme, commonly known as GBM or glioblastoma is a grade IV astrocytoma. Brain tumors are difficult to treat and lead to poor prognosis and survival in patients. Gliomas are categorized into four different grades among which GBM is the worst grade primary brain tumor with a survival of less than a year. The genomic heterogeneity of the brain tumor results in different profiles for patients diagnosed with glioblastoma. Precision medicine focuses on this specific tumor type and suggests specialized treatment for better prognosis and overall survival (OS).With the recent advancements in Genome-Wide Studies (GWS) and various characterizations of brain tumors based on genetic, transcriptomic, proteomic, epigenetic, and metabolomics, this review discusses the advancements and opportunities of precision medicine therapeutics, drugs, and diagnosis methods based on the different profiles of glioblastoma.This review has exhaustively surveyed several pieces of works from various literature databases.It is evident that most primary brain tumors including glioblastoma require specific and precision therapeutics for better prognosis and OS. In present and future, molecular understanding and discovering specific therapies are essential for treatment in the field of neurooncology.© the Author(s).