癌症是导致死亡的主要原因之一，已经测试并使用了多种方法来找出最佳治疗方法。除了靶向治疗外，免疫疗法已被证明通过控制某些免疫细胞是有效的。传统的癌症治疗会遇到不良副作用的后果，这一直是治疗的一个主要问题；因此，人们向天然存在的免疫调节剂迈进，以开发更安全的治疗方法。调节性 T 细胞 (Treg) 是负责肿瘤生长的主要免疫细胞之一。为了维持免疫稳态，Treg 抑制对自身和非自身抗原的异常免疫反应。转录因子 FoxP3 负责其谱系规范，并参与 IL10、IL35 和 TGFb 等免疫抑制细胞因子的产生。这有助于癌细胞增殖，而不受 CD8 T 细胞、树突状细胞、单核细胞/巨噬细胞、B 细胞和自然杀伤细胞等不同免疫细胞的限制。因此，针对 Tregs 提供不受阻碍的免疫监视已被证明是癌症免疫治疗的突破。这篇综述主要关注一些常见的天然免疫调节剂，这些免疫调节剂源自植物产品，这些产品已成为免疫治疗剂，以及它们抑制 Tregs 的一些能力，可作为治疗癌症的有效方法。版权所有 © Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Cancer is one of the leading causes of death, and numerous methods have been tested and used to figure out an optimum way of treatment. Besides targeted therapy, immunotherapy has proven to be effective by controlling certain immune cells. Traditional cancer therapy is met with the consequences of adverse side effects that have been a major issue for treatment; hence, a leap towards naturally occurring immunomodulators was taken to develop safer methods of treatment. One of the major immune cells responsible for the growth of tumors is regulatory T cells (Tregs). To maintain immunological homeostasis, Treg dampens abnormal immune responses to self and non-self-antigens. The transcription factor FoxP3 is responsible for their lineage specification and takes part in the production of immunosuppressive cytokines like IL10, IL35, and TGFb. This helps cancer cells to proliferate without the restriction of different immune cells like CD8+T cells, dendritic cells, monocytes/macrophages, B cells, and natural killer cells. Hence, targeting Tregs to provide unhindered immunosurveillance has proven to be a breakthrough in cancer immunotherapy. This review mainly focuses on some common naturally occurring immunomodulators derived from plant products that have earned their place as immunotherapeutic agents, along with some of their ability to suppress Tregs that can be used as an effective way to treat cancer.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.