细胞应激和免疫循环是机体稳态的基石。压力激活组织或器官内的细胞内和细胞间通讯，启动适应性反应，旨在解决压力的根源。如果这些局部措施无法缓解这种压力，那么细胞间通讯就会扩展到免疫激活，目的是招募免疫细胞来有效解决这种情况，同时执行组织修复以减轻任何损伤并促进体内平衡。这种细胞应激-免疫循环在癌症等疾病环境中严重失调。一方面，癌细胞会失调正常的细胞应激反应，以重新调整它们的方向，不惜一切代价维持生长，甚至以牺牲有机体完整性和体内平衡为代价。另一方面，肿瘤严重失调或抑制机体免疫的各个组成部分，例如，通过促进免疫抑制肿瘤景观、降低抗原性和增加 T 细胞功能障碍。在这篇综述中，我们的目的是全面讨论细胞应激-免疫循环的肿瘤失调背后的基础。我们还提供了对当前对该周期的监管者和放松监管者的理解的见解，以及如何将它们作为概念化成功的癌症免疫治疗方案的目标。© 2023 John Wiley

The cellular stress and immunity cycle is a cornerstone of organismal homeostasis. Stress activates intracellular and intercellular communications within a tissue or organ to initiate adaptive responses aiming to resolve the origin of this stress. If such local measures are unable to ameliorate this stress, then intercellular communications expand toward immune activation with the aim of recruiting immune cells to effectively resolve the situation while executing tissue repair to ameliorate any damage and facilitate homeostasis. This cellular stress-immunity cycle is severely dysregulated in diseased contexts like cancer. On one hand, cancer cells dysregulate the normal cellular stress responses to reorient them toward upholding growth at all costs, even at the expense of organismal integrity and homeostasis. On the other hand, the tumors severely dysregulate or inhibit various components of organismal immunity, for example, by facilitating immunosuppressive tumor landscape, lowering antigenicity, and increasing T-cell dysfunction. In this review we aim to comprehensively discuss the basis behind tumoral dysregulation of cellular stress-immunity cycle. We also offer insights into current understanding of the regulators and deregulators of this cycle and how they can be targeted for conceptualizing successful cancer immunotherapy regimen.© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.