研究动态
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短期左结肠切除术治疗结肠癌:安全吗?

Short-Stay Left Colectomy for Colon Cancer: Is It Safe?

发表日期:2023 Nov 08
作者: Angelos Papanikolaou, Sophia Y Chen, Shannon N Radomski, Miloslawa Stem, Lawrence B Brown, Vincent J Obias, Ada E Graham, Haniee Chung
来源: JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

摘要:

手术实践的进步缩短了术后住院时间 (LOS)。本研究的目的是确定美国结肠癌患者接受短期(≤24 小时)左半结肠切除术的安全性。使用 ACS-NSQIP 数据库(2012 年)确定了接受选择性左半结肠切除术的成年结肠癌患者。 -2021)。患者被分为四个LOS组:LOS≤1天(≤24小时短期停留)、2-4天、5-6天和≥7天。主要结局是术后 30 天的总体情况和严重发病率。次要结局是 30 天死亡率和再入院率。采用多变量逻辑回归来探讨 LOS 与总体发病率和严重发病率之间的关联。共有 15,745 名因结肠癌接受左侧结肠切除术的患者,其中 294 名患者 (1.87%) 接受短期住院治疗。短期住院患者普遍更年轻、更健康,30 天总体发病率较低(LOS ≤1 天:3.74%,LOS 2-4:7.38%,LOS 5-6:16.12%,LOS ≥7:37.64%, p<0.001)。与 LOS 2-4 天的患者相比,死亡率和再入院率没有差异。调整分析显示,总体发病率(LOS 2-4 天 OR 1.90,95% CI 1.01-3.60,p=0.049)和严重发病率(LOS 2-4 天 OR 0.86,95% CI 1.42)没有统计学差异。 -1.76,p=0.672) 短期住院组和 LOS 2-4 天组之间。尽管目前在美国的实施率较低,但短期住院左侧结肠切除术对于某些特定患者组是安全的。关注患者选择、临床路径的完善和密切随访可能会使短期结肠切除术成为更加可行的现实。版权所有 © 2023 美国外科医生学会。由 Wolters Kluwer Health, Inc. 出版。保留所有权利。
Advances in surgical practices have decreased hospital length of stay (LOS) after surgery. The purpose of this study was to determine the safety of short-stay (≤24-hour) left colectomy for colon cancer patients in the United States.Adult colon cancer patients who underwent elective left colectomies were identified using the ACS-NSQIP database (2012-2021). Patients were categorized into four LOS groups: LOS ≤1 day (≤24-hour short-stay), 2-4 days, 5-6 days, and ≥7 days. Primary outcomes were 30-day postoperative overall and serious morbidity. Secondary outcomes were 30-day mortality and readmission. Multivariable logistic regression was performed to explore the association between LOS and overall and serious morbidity.A total of 15,745 patients who underwent left colectomies for colon cancer were identified with 294 patients (1.87%) undergoing short-stay. Short-stay patients were generally younger and healthier with lower 30-day overall morbidity rates (LOS ≤1 day: 3.74%, LOS 2-4: 7.38%, LOS 5-6: 16.12%, and LOS ≥7: 37.64%, p<0.001). Compared to patients with LOS 2-4 days, no differences in mortality and readmission rates were observed. On adjusted analysis, there was no statistical difference in the odds of overall (LOS 2-4 days OR 1.90, 95% CI 1.01-3.60, p=0.049) and serious morbidity (LOS 2-4 days OR 0.86, 95% CI 1.42-1.76, p=0.672) between the short-stay and LOS 2-4 days groups.Although currently performed at low rates in the U.S., short-stay left colectomy is safe for a select group of patients. Attention to patient selection, refinement of clinical pathways, and close follow-up may enable short-stay colectomies to become a more feasile reality.Copyright © 2023 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.