金属有机框架（MOF）因其装载和释放不同货物的内在能力而成为有前途的药物输送平台。为了进一步扩展其生物医学实践，开发具有良好生物相容性和协同功效的协作MOF系统至关重要。在此，构建了近红外和pH双重响应协同沸石咪唑酯框架8（ZIF-8）平台SOR@ZIF-8@PDA（SZP），其中化疗药物索拉非尼（SOR）被封装在ZIF-8中。 8 并通过分层自组装在 ZIF-8 上涂上聚多巴胺 (PDA)。 PDA涂层作为PPT的光热剂，同时降低ZIF-8的毒性。 SZP通过响应肿瘤微环境的较低pH值和近红外光照射产生的热刺激，实现治疗药物的智能释放。此外，在光照射下，SZP可以通过协同化学光热疗法有效实现对癌细胞的治疗，增强细胞凋亡，抑制肿瘤细胞增殖和迁移。这种协同 MOF 系统在小鼠 HepG2 肿瘤模型上表现出优异的生物相容性和体内抗肿瘤能力。我们的结果表明，PDA 修饰的 MOFs 在生物医学应用中表现出良好的发展前景。

Metal-organic frameworks (MOFs) are promising drug-delivering platforms for their intrinsic capability of loading and releasing different cargoes. To further extend their biomedical practices, the development of collaborative MOF systems with good biocompatibility and synergistic efficacy is essential. Herein, the near-infrared and pH dual-response collaborative zeolitic imidazolate framework-8 (ZIF-8) platform SOR@ZIF-8@PDA (SZP) was constructed, in which the chemotherapeutic drug sorafenib (SOR) was encapsulated in ZIF-8 and via polydopamine (PDA) coating on ZIF-8 by hierarchical self-assembly. PDA coating serves as a photothermal agent for PPT while reducing the toxicity of ZIF-8. SZP achieves intelligent release of therapeutic drugs by responding to the lower pH of the tumor microenvironment and thermal stimulation generated by near-infrared light irradiation. In addition, under light irradiation, SZP could effectively realize treatment of cancer cells through synergistic chemo-photothermal therapy, as evidenced by the enhanced cell apoptosis, inhibited tumor cell proliferation and migration. This collaborative MOFs system showed excellent biocompatibility and antitumor ability in vivo on a mouse HepG2 tumor model. Our results demonstrated that PDA-modified MOFs exhibited a fantastic good development prospect in biomedical applications.