恶性黑色素瘤是由皮肤、粘膜和葡萄膜产生的最具侵袭性的肿瘤之一，很容易转移。骨组织是最典型的远处转移部位之一，约5%-20%的患者最终发生骨骼转移。几十年来，随着靶向治疗和免疫治疗的进步，骨转移的发病率较高，给家庭、社会和医疗系统带来了更大的负担，大大延长了患者的生存时间。此外，骨转移会导致骨骼相关事件，这显然会影响生活质量。因此，适当的干预至关重要。为了获得最佳的成本效益，必须整合现有的治疗算法，这仍然存在争议。我们的目的是阐明有关黑色素瘤骨转移的形成、生物学和临床特征以及治疗方案的当前观点，以指导决策过程。版权所有 © 2023 Wolters Kluwer Health, Inc. 保留所有权利。

One of the most aggressive tumors arising from the skin, mucosa, and uvea is malignant melanoma, which easily metastasizes. Bone tissue is one of the most typical locations for distant metastasis, and around 5%-20% of patients eventually acquired skeletal metastases. For decades, the incidence of bone metastases was higher, bringing greater burden on the family, society, and healthcare system owing to the progress of targeted therapy and immunotherapy, which prolonging the survival time substantially. Moreover, bone metastases result in skeletal-related events, which influence the quality of life, obviously. Appropriate intervention is therefore crucial. To obtain the optimum cost-effectiveness, existing treatment algorithm must be integrated, which is still controversial. We have aimed to throw light on current views concerning the formation, biological and clinical features, and treatment protocol of melanoma bone metastases to guide the decision-making process.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.