作为癌症的新标志之一，脂质代谢重编程最近变得令人着迷并得到广泛研究。癌症中的脂质代谢重编程通过产生 ATP、生物合成大分子和维持适当的氧化还原状态来支持癌发生、进展、远端转移和化疗耐药。值得注意的是，越来越多的证据证实，脂质代谢重编程受到癌症中失调的非编码 RNA 的控制，尤其是 lncRNA 和 circRNA。这篇综述重点介绍了目前关于参与癌症脂质代谢重编程的异常表达的 lncRNA 和 circRNA 的研究结果。重点放在脂质代谢重编程和相关机制中的调节目标，包括通过脂质代谢调节与癌症的临床相关性。这些见解对于为患有脂质代谢重编程的癌症患者确定新的治疗诊断目标和治疗策略至关重要。© 2023 作者。 《先进科学》由 Wiley-VCH GmbH 出版。

As one of novel hallmarks of cancer, lipid metabolic reprogramming has recently been becoming fascinating and widely studied. Lipid metabolic reprogramming in cancer is shown to support carcinogenesis, progression, distal metastasis, and chemotherapy resistance by generating ATP, biosynthesizing macromolecules, and maintaining appropriate redox status. Notably, increasing evidence confirms that lipid metabolic reprogramming is under the control of dysregulated non-coding RNAs in cancer, especially lncRNAs and circRNAs. This review highlights the present research findings on the aberrantly expressed lncRNAs and circRNAs involved in the lipid metabolic reprogramming of cancer. Emphasis is placed on their regulatory targets in lipid metabolic reprogramming and associated mechanisms, including the clinical relevance in cancer through lipid metabolism modulation. Such insights will be pivotal in identifying new theranostic targets and treatment strategies for cancer patients afflicted with lipid metabolic reprogramming.© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.