植物源性抗肿瘤天然产物的发现:抗肿瘤药物发现的潜在线索。
Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery.
发表日期:2023 Nov 04
作者:
Zi Hui, Hao Wen, Junlong Zhu, Haowen Deng, Xiaoying Jiang, Xiang-Yang Ye, Liwei Wang, Tian Xie, Renren Bai
来源:
BIOORGANIC CHEMISTRY
摘要:
天然产物是新药的重要来源。许多植物源性天然产物已表现出有效的抗肿瘤特性,因此它们作为抗肿瘤药物的潜力引起了人们的极大兴趣。这篇综述对 2018 年至今的 242 种最近发现的天然产品进行了概述。这些天然产物包括69种萜类化合物、42种生物碱、39种黄酮类化合物、21种类固醇、14种苯丙素类化合物、5种喹啉类化合物和52种其他化合物,具有各自的化学结构、抗肿瘤活性和作用机制。通过提供重要的参考和新鲜的见解,本综述旨在支持和激励从事天然产物和抗肿瘤药物发现领域的研究人员。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Natural products represent a paramount source of novel drugs. Numerous plant-derived natural products have demonstrated potent anti-tumor properties, thereby garnering considerable interest in their potential as anti-tumor drugs. This review compiles an overview of 242 recently discovered natural products, spanning the period from 2018 to the present. These natural products, which include 69 terpenoids, 42 alkaloids, 39 flavonoids, 21 steroids, 14 phenylpropanoids, 5 quinolines and 52 other compounds, are characterized by their respective chemical structures, anti-tumor activities, and mechanisms of action. By providing an essential reference and fresh insights, this review aims to support and inspire researchers engaged in the fields of natural products and anti-tumor drug discovery.Copyright © 2023 Elsevier Inc. All rights reserved.