该研究旨在描述口腔或口咽癌 (OCOP) 患者的内淋巴水肿、外淋巴水肿和纤维化的患病率、严重程度和轨迹。120 名新诊断的 OCOP 癌症患者被纳入一项前瞻性纵向研究。招募是在一家综合医疗中心进行的。参与者在治疗前、治疗结束、癌症治疗后 3、6、9 和 12 个月时接受评估。使用经过验证的临床医生报告的措施和 CT 成像来评估研究结果。本报告纳入了 76 名完成 9 或 12 个月评估的患者。 1）外部淋巴水肿和纤维化轨迹：总严重程度评分在治疗结束至治疗后3个月期间达到峰值；随着时间的推移逐渐减少，但到治疗后 12 个月仍未恢复至基线 (p < .001)。仅接受手术治疗或接受多学科治疗的患者的严重程度评分的纵向模式相似。 2) 内部肿胀轨迹：所有患者在治疗后立即表现出肿胀部位显着增加。对于仅接受手术治疗的患者，肿胀很小，并在治疗后 9 至 12 个月恢复到基线。接受多模式治疗的患者在治疗后 12 个月期间肿胀部位数量逐渐减少，但仍显着高于基线 (p < .05)。 3）CT成像：在治疗后12个月期间，单纯手术治疗组和综合治疗组观察到椎前软组织和会厌厚度的不同变化模式。在仅进行手术的组中，任一区域的厚度变化都很小。接受多模式治疗的患者在治疗后 3 个月时两个区域的厚度均显着增加，并且在 12 个月时仍然比基线更厚 (p <.001)。淋巴水肿和纤维化是 OCOP 癌症治疗的常见并发症。淋巴水肿和纤维化的常规评估、监测和及时治疗至关重要。版权所有 © 2023 Elsevier Ltd。保留所有权利。

The study aimed to describe the prevalence, severity, and trajectory of internal lymphedema, external lymphedema, and fibrosis in patients with oral cavity or oropharyngeal (OCOP) cancer.120 patients with newly diagnosed OCOP cancer were enrolled in a prospective longitudinal study. Recruitment was conducted at a comprehensive medical center. Participants were assessed at pre-treatment, end-of-treatment, 3-, 6-, 9-, and 12-month post-cancer treatment. Validated clinician-reported measures and CT imaging were used to assess the study outcomes.76 patients who completed the 9- or 12-month assessments were included in this report. 1) External lymphedema and fibrosis trajectories: The total severity score peaked between end-of-treatment and 3 months post-treatment; reduced gradually over time but did not return to baseline by 12 months post-treatment (p < .001). The longitudinal patterns of severity scores for patients treated with surgery only or with multimodality therapy were similar. 2) Internal swelling trajectories: All patients demonstrated a significant increase in sites with swelling immediately post-treatment. For patients treated with surgery only, swelling was minimal and returned to baseline by 9- to 12 months post-treatment. Patients receiving multi-modal treatment demonstrated a gradual decrease in number of sites with swelling during the 12-month post-treatment period yet remained significantly above baseline (p < .05). 3) CT imaging: Different patterns of changes in prevertebral soft tissue and epiglottic thickness were observed in the surgery-only and multimodality treatment groups during the 12-month post-treatment period. There were minimal changes in thickness in either region in the surgery-only group. Patients with multi-modal treatment had significant increases in thickness in both regions 3 months post-treatment which remained thicker at 12 months than it was at baseline (p <.001).Lymphedema and fibrosis are common complications of OCOP cancer therapy. Routine assessment, monitoring, and timely treatment of lymphedema and fibrosis are critical.Copyright © 2023 Elsevier Ltd. All rights reserved.