聚焦超声（FUS）的消融作用在过去的几十年里在生物医学领域发挥着越来越重要的作用，其非侵入性的特点具有很大的优势，特别是对于无法或不适合手术治疗的临床疾病。近年来，声激活材料的可调节形态、模拟酶活性和生物稳定性方面的快速进展极大地促进了FUS消融的医学应用。然而，目前还没有对基于 FUS 消融的声激活材料进行系统评价。本进展综述重点关注声激活材料在 FUS 消融生物医学领域的最新设计、基本原理和应用。首先，仔细确定不同的消融机制和影响消融的关键因素。然后，全面讨论了具有高 FUS 消融效率的声激活材料的设计。随后，详细总结了代表性的生物学应用。最后，还概述了主要挑战和未来前景。我们相信，这次及时的审查将为进一步探索聚焦超声消融提供关键信息和见解，并为设计未来声激活材料提供新的灵感。意义声明：过去几十年来，聚焦超声（FUS）的消融效应在生物医学领域发挥着越来越重要的作用。但FUS消融也存在一些挑战，如皮肤烧伤、热消融后肿瘤复发、空化消融难以控制等。声激活材料的可调节形态、模拟酶活性和生物稳定性的快速进步极大地促进了FUS消融的医学应用。然而，基于 FUS 消融的声激活材料的系统评价尚不可用。本进展综述重点关注声激活材料 FUS 消融生物医学领域的最新设计、基本原理和应用。我们相信这次及时的审查将为进一步探索 FUS 消融提供关键信息和见解。版权所有 © 2023。由 Elsevier Ltd 出版。

The ablation effect of focused ultrasound (FUS) has played an increasingly important role in the biomedical field over the past decades, and its non-invasive features have great advantages, especially for clinical diseases where surgical treatment is not available or appropriate. Recently, rapid advances in the adjustable morphology, enzyme-mimetic activity, and biostability of sono-activated materials have significantly promoted the medical application of FUS ablation. However, a systematic review of sono-activated materials based on FUS ablation is not yet available. This progress review focuses on the recent design, fundamental principles, and applications of sono-activated materials in the FUS ablation biomedical field. First, the different ablation mechanisms and the key factors affecting ablation are carefully determined. Then, the design of sono-activated materials with high FUS ablation efficiencies is comprehensively discussed. Subsequently, the representative biological applications are summarized in detail. Finally, the primary challenges and future perspectives are also outlined. We believe this timely review will provide key information and insights for further exploration of focused ultrasound ablation and new inspiration for designing future sono-activated materials. STATEMENT OF SIGNIFICANCE: The ablation effect of focused ultrasound (FUS) has played an increasingly important role in the biomedical field over the past decades. However, there are also some challenges of FUS ablation, such as skin burns, tumor recurrence after thermal ablation, and difficulty in controlling cavitation ablation. The rapid advance in adjustable morphology, enzyme-mimetic activity, and biostability of sono-activated materials has significantly promoted the medical application of FUS ablation. However, the systematic review of sono-activated materials based on FUS ablation is not yet available. This progress review focuses on the recent design, fundamental principles, and applications in the FUS ablation biomedical field of sono-activated materials. We believe this timely review will provide key information and insights for further exploration of FUS ablation.Copyright © 2023. Published by Elsevier Ltd.