线粒体是参与各种理化和生化过程的细胞的主要细胞器。由于其在细胞代谢中的关键作用，线粒体是治疗和预防癌症的首选治疗靶点。最近，人们对使用线粒体特异性功能纳米粒子将治疗剂靶向递送到这些细胞器越来越感兴趣。在几种纳米系统中，脂质体由于其卓越的药物输送能力、生物相容性、生物降解性、易于制造以及已建立的市场批准监管指南而引起了相当大的关注。在这种背景下，本综述简要介绍了线粒体与肿瘤形成之间的关联以及线粒体靶向在癌症治疗中的优势。此外，它还讨论了用于治疗各种癌症（如乳腺癌、肺癌、结肠癌等）的线粒体靶向功能性脂质体。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Mitochondria are the primary organelles of cells involved in various physiochemical and biochemical processes. Owing to their crucial role in cellular metabolism, mitochondria are favored therapeutic targets for the treatment and prevention of cancers. Recently, there has been growing interest in the use of mitochondria-specific functional nanoparticles for targeted delivery of therapeutic agents to these organelles. Among several nanosystems, liposomes have garnered considerable attention owing to their exceptional drug delivery capabilities, biocompatibility, biodegradability, ease of manufacturing and established regulatory guidelines for market approval. In this context, the present review provides a brief insight into the association between mitochondria and tumor formation and advantages of mitochondrial targeting in cancer therapy. Furthermore, it discusses mitochondria-targeting functional liposomes for the treatment of various cancers, such as breast, lung, colon, among others.Copyright © 2023 Elsevier Ltd. All rights reserved.