血管生成是新血管形成的过程，是肿瘤生长和转移所必需的。它有助于为肿瘤细胞提供氧气和营养，在乳腺癌的局部进展、远处转移以及耐药性的发展中发挥着至关重要的作用。肿瘤血管生成目前被认为是一个关键的治疗靶点；然而，乳腺癌的抗血管生成治疗由于疗效不一致、不良反应明显等问题，未能取得令人满意的效果。因此，迫切需要新的抗血管生成药物。类黄酮是一类存在于许多食品中的天然化合物，价格低廉、用途广泛，并具有广泛的生物活性、低毒性和良好的安全性。多项研究发现，各种黄酮类化合物可抑制乳腺癌的血管生成，表明其具有巨大的治疗潜力。在这篇综述中，我们总结了血管生成在乳腺癌中的作用以及天然黄酮类化合物作为抗血管生成剂用于乳腺癌治疗的潜力。我们讨论了纳米技术对于提高类黄酮吸收利用和抗血管生成作用的价值和意义，以及使用天然类黄酮作为药物的挑战。本文受版权保护。版权所有。

Angiogenesis is the process by which new blood vessels form and is required for tumor growth and metastasis. It helps in supplying oxygen and nutrients to tumor cells and plays a crucial role in the local progression and distant metastasis of, and development of treatment resistance in breast cancer. Tumor angiogenesis is currently regarded as a critical therapeutic target; however, anti-angiogenic therapy for breast cancer fails to produce satisfactory results, owing to issues such as inconsistent efficacy and significant adverse reactions. As a result, new anti-angiogenic drugs are urgently needed. Flavonoids, a class of natural compounds found in many foods, are inexpensive, widely available, and exhibit a broad range of biological activities, low toxicity, and favorable safety profiles. Several studies find that various flavonoids inhibit angiogenesis in breast cancer, indicating great therapeutic potential. In this review, we summarize the role of angiogenesis in breast cancer and the potential of natural flavonoids as anti-angiogenic agents for breast cancer treatment. We discuss the value and significance of nanotechnology for improving flavonoid absorption and utilization and anti-angiogenic effects, as well as the challenges of using natural flavonoids as drugs.This article is protected by copyright. All rights reserved.