肿瘤沉积物被定义为所有类型的孤立的癌症病变，没有被视为淋巴结一部分的淋巴细胞聚集体。据报道，肿瘤沉积是一个负面的预后因素。然而，分类肿瘤沉积物的生存意义尚不确定，特别是在胃癌中。本研究旨在探讨不同类型肿瘤沉积物之间的预后差异。纳入因胃癌接受胃切除术的患者。所有肿瘤沉积物分为不规则结节、不规则结节星形、光滑结节和血管/神经侵犯。有些病例有超过 2 类肿瘤沉积物。在以下分析中，这些病例被归类为肿瘤沉积物复合体。我们对有肿瘤沉积物和无肿瘤沉积物的患者进行生存分析，并比较各类肿瘤沉积物之间的生存率。在 868 名患者中，有和无肿瘤沉积物的患者分别为 96 名（11.1％）和 772 名（88.9％）。血管/神经侵犯、光滑结节、不规则结节、不规则结节星形和肿瘤沉积物复合体见 6 例（6.3%）、15 例（15.6%）、43 例（44.8%）、1 例（1.0%）和 31 例（ 32.3%）患者。有肿瘤沉积的患者的生存率比没有肿瘤沉积的患者要差。 3 年总生存率：肿瘤沉积物阴性 = 87.0%，肿瘤沉积物阳性 = 53.2% (P < .001)。生存分析显示肿瘤沉积可能是一个预后风险因素（风险比：1.9854，95% 置信区间：1.393-2.830，P < .01）。不规则结节和肿瘤沉积物复合体的预后最差（不规则结节 3 年总生存率：51.2%，肿瘤沉积物复合物 3 年总生存率：41.9%，P = .001），而平滑结节则表现出更好的预后（平滑结节） 3年总生存率：80%）。肿瘤沉积物对胃癌的生存产生负面影响。不规则结节和肿瘤沉积物复合体显示出很强的预后作用。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Tumor deposits are defined as all types of isolated cancer lesions without lymphocyte aggregates considered part of the lymph node. Tumor deposits have been reported as a negative prognostic factor. However, the survival significance of categorized tumor deposits is uncertain, particularly in gastric cancer. This study aimed to investigate the prognostic difference among categorized tumor deposits.Patients who underwent gastrectomy for gastric cancer were enrolled. All tumor deposits were categorized into irregular nodule, irregular nodule star, smooth nodule, and vascular/neural invasion. There are some cases with more than 2 categorized tumor deposits. These cases were categorized as tumor deposit complex in the following analysis. We performed survival analysis between the patients with and without tumor deposits, and compared the survival among each categorized tumor deposit.Of 868 patients, there were 96 (11.1%) and 772 (88.9%) patients with and without tumor deposits. Vascular/neural invasion, smooth nodule, irregular nodule, irregular nodule star, and the tumor deposits complex was observed in 6 (6.3%), 15 (15.6%), 43 (44.8%), 1 (1.0%), and 31 (32.3%) patients. Patients with tumor deposits displayed poorer survival than those without; the 3-year overall survival: tumor deposits negative = 87.0%, tumor deposits positive = 53.2% (P < .001). Survival analysis revealed tumor deposits can be a prognostic risk factor (hazard ratio: 1.9854, 95% confidence interval: 1.393-2.830, P < .01). Irregular nodule and the tumor deposits complex demonstrated the worst prognosis (irregular nodule 3-year overall survival: 51.2%, tumor deposits complex 3-year overall survival: 41.9%, P = .001), whereas smooth nodule demonstrated better prognosis (smooth nodule 3-year overall survival: 80%).Tumor deposits exerted a negative survival effect in gastric cancer. Irregular nodule and the tumor deposits complex displayed a strong prognostic effect.Copyright © 2023 Elsevier Inc. All rights reserved.