随着有机锗和纳米技术的发展，锗具有多种生物功能，其在生物化学和医学方面的潜在价值日益引起研究人员的关注。近年来，锗作为一种材料在生物医学领域逐渐受到重视，并展现出广阔的应用前景。然而，目前对锗的生物效应和机制的研究还很有限，还缺乏系统的评价。因此，本综述的目的是系统探讨锗在生物医学领域的应用，为未来锗在疾病治疗中的功能和机制的研究提供新的见解。通过对MEDLINE、EMBASE、Web of Science数据库进行全面检索，系统回顾了锗与生物医学关系的相关文献。在这篇综述中，我们将描述锗在炎症、免疫和抗氧化方面的生物活性。此外，我们将讨论它在治疗神经科学和肿瘤学相关疾病中的作用。对锗的这种全面探索为该元素未来在疾病干预、诊断和预防中的应用提供了宝贵的基础。© 2023。作者。

With the development of organic germanium and nanotechnology, germanium serves multiple biological functions, and its potential value in biochemistry and medicine has increasingly captured the attention of researchers. In recent years, germanium has gradually gained significance as a material in the field of biomedicine and shows promising application prospects. However, there has been a limited amount of research conducted on the biological effects and mechanisms of germanium, and a systematic evaluation is still lacking. Therefore, the aim of this review is to systematically examine the application of germanium in the field of biomedicine and contribute new insights for future research on the functions and mechanisms of germanium in disease treatment. By conducting a comprehensive search on MEDLINE, EMBASE, and Web of Science databases, we systematically reviewed the relevant literature on the relationship between germanium and biomedicine. In this review, we will describe the biological activities of germanium in inflammation, immunity, and antioxidation. Furthermore, we will discuss its role in the treatment of neuroscience and oncology-related conditions. This comprehensive exploration of germanium provides a valuable foundation for the future application of this element in disease intervention, diagnosis, and prevention.© 2023. The Author(s).