前列腺癌仍然是全球男性癌症相关死亡的最常见原因之一。前列腺癌进展为致命性转移性疾病是由多种因素介导的。前列腺微生物群及其代谢物在转移、去势抵抗性前列腺癌（CRPC）治疗抵抗和肿瘤复发中的作用尚未得到充分研究。微生物区系的表征可以为治疗耐药性的出现、新型有效靶向疗法的鉴定以及前列腺癌进展过程中生物标志物的开发中的功能意义提供新的机制见解。肿瘤微环境（TME）及其组成部分与前列腺微生物群同时作用，促进前列腺癌的发生和进展至转移。在本文中，我们讨论了越来越多的证据，表明微生物群对 TME 表型景观的功能贡献及其对前列腺癌治疗靶向和复发性疾病的影响。AJCEU 版权所有 © 2023。

Prostate cancer remains one of the most common causes of cancer-related death in men globally. Progression of prostate cancer to lethal metastatic disease is mediated by multiple contributors. The role of prostate microbiota and their metabolites in metastasis, therapeutic resistance to castration resistant prostate cancer (CRPC), and tumor relapse has yet to be fully investigated. Characterization of microflora can provide new mechanistic insights into the functional significance in the emergence of therapeutic resistance, identification of novel effective targeted therapies, and development of biomarkers during prostate cancer progression. The tumor microenvironment (TME) and its components work concurrently with the prostate microbiota in promoting prostate cancer development and progression to metastasis. In this article, we discuss the growing evidence on the functional contribution of microbiota to the phenotypic landscape of the TME and its effect on prostate cancer therapeutic targeting and recurrent disease.AJCEU Copyright © 2023.