堇菜属 (Viola L.) 是堇菜科中最大的属，在全球有 500 多个物种。目前广泛的文献调查表明，堇菜属植物是一组重要的营养和药用植物，用于民族医学治疗糖尿病、哮喘、肺部疾病和疲劳等非传染性疾病（NCD）。该属的许多植物物种的药理活性也得到了科学验证，包括神经保护、免疫调节、抗癌、抗高血压、抗血脂异常、镇痛、解热、利尿、抗炎、驱虫和抗氧化剂。堇菜富含不同的天然产物，其中一些在过去几十年中已被分离和鉴定。这些包括具有不同药理活性的黄酮类、萜类和苯丙类。目前对该属植物的药代动力学和临床研究尚缺乏，本综述旨在总结目前对堇菜属药用植物的民族药理学、植物化学、营养成分和药理概况的认识，揭示其治疗潜力、差距和作用。随后为未来的药理学研究打开了一个新窗口。版权所有 © 2023 Gaber El-Saber Batiha 等人。

Viola L. is the largest genus of the Violaceae family with more than 500 species across the globe. The present extensive literature survey revealed Viola species to be a group of important nutritional and medicinal plants used for the ethnomedicinal treatment of noncommunicable diseases (NCDs) such as diabetes, asthma, lung diseases, and fatigue. Many plant species of this genus have also received scientific validation of their pharmacological activities including neuroprotective, immunomodulatory, anticancer, antihypertensive, antidyslipidemic, analgesic, antipyretic, diuretic, anti-inflammatory, anthelmintic, and antioxidant. Viola is highly rich in different natural products some of which have been isolated and identified in the past few decades; these include flavonoids terpenoids and phenylpropanoids of different pharmacological activities. The pharmacokinetics and clinical studies on this genus are lacking, and the present review is aimed at summarizing the current understanding of the ethnopharmacology, phytochemistry, nutritional composition, and pharmacological profile of medicinal plants from the Viola genus to reveal its therapeutic potentials, gaps, and subsequently open a new window for future pharmacological research.Copyright © 2023 Gaber El-Saber Batiha et al.