MYC 是 Myc 原癌基因家族的关键成员，是一种通用转录放大器，可调节细胞中几乎所有的生理过程，包括细胞周期、增殖、代谢、分化和凋亡。 MYC 与多种辅助因子、染色质修饰剂和调节因子相互作用来指导基因表达。 MYC 水平受到严格调节，MYC 的失调与包括癌症在内的多种疾病有关。了解 MYC 在生理条件下的综合生物学特性对于区分 MYC 的生物学功能和病理功能至关重要。本文综述了 MYC 的生物学机制、功能和调控的最新进展。我们还强调 MYC 作为全局转录放大器的作用。版权所有 © 2023 Jha、Kouzine 和 Levens。

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression. MYC levels are tightly regulated, and deregulation of MYC has been associated with numerous diseases including cancer. Understanding the comprehensive biology of MYC under physiological conditions is an utmost necessity to demark biological functions of MYC from its pathological functions. Here we review the recent advances in biological mechanisms, functions, and regulation of MYC. We also emphasize the role of MYC as a global transcription amplifier.Copyright © 2023 Jha, Kouzine and Levens.