近年来，生长激素 (GH)-胰岛素样生长因子-1 (IGF1) 信号通路成为衰老和长寿的关键决定因素。在不同的动物物种（包括苍蝇、线虫和小鼠）中，该网络的破坏始终与寿命的延长有关。流行病学分析表明，拉伦综合征 (LS) 是先天性 IGF1 缺陷下最典型的疾病，患者似乎可以预防癌症。虽然衰老和癌症通常被认为是截然相反的过程，但现代证据强化了这样的观念：事实上，衰老和癌症可能被视为相同生化和细胞基础过程的不同表现。虽然个体突变对寿命和健康寿命的影响很难评估，但全基因组筛查在 LS 患者中发现了许多具有差异性的衰老和长寿相关基因。本综述总结了对 LS 患者进行综合分析的最新数据，并描绘了许多以前未被识别的 GH-IGF1 作用靶点。我们的文章阐明了复杂的衰老和长寿过程，特别强调了 GH-IGF1 网络在这些机制中的作用。版权所有 © 2023 Werner 和 Laron。

The growth hormone (GH)-insulin-like growth factor-1 (IGF1) signaling pathway emerged in recent years as a key determinant of aging and longevity. Disruption of this network in different animal species, including flies, nematodes and mouse, was consistently associated with an extended lifespan. Epidemiological analyses have shown that patients with Laron syndrome (LS), the best-characterized disease under the umbrella of the congenital IGF1 deficiencies, seem to be protected from cancer. While aging and cancer, as a rule, are considered diametrically opposite processes, modern lines of evidence reinforce the notion that aging and cancer might, as a matter of fact, be regarded as divergent manifestations of identical biochemical and cellular underlying processes. While the effect of individual mutations on lifespan and health span is very difficult to assess, genome-wide screenings identified a number of differentially represented aging- and longevity-associated genes in patients with LS. The present review summarizes recent data that emerged from comprehensive analyses of LS patients and portrays a number of previously unrecognized targets for GH-IGF1 action. Our article sheds light on complex aging and longevity processes, with a particular emphasis on the role of the GH-IGF1 network in these mechanisms.Copyright © 2023 Werner and Laron.