根据激素分泌，胰腺神经内分泌肿瘤可分为功能性或非功能性。每个实体的治疗都不同，非功能性肿瘤采用传统化疗治疗，而功能性肿瘤对抗激素治疗和免疫药物反应良好。非功能性肿瘤转变为功能性肿瘤是极其罕见的事件，这使得这些患者的整体管理变得复杂。在本报告中，我们介绍了一位 73 岁女性的病例，她从无功能性肿瘤转变为功能性肿瘤，并讨论了所考虑的治疗方案。© 2023 作者。约翰·威利 (John Wiley) 出版的临床病例报告

Pancreatic neuroendocrine tumors can be classified as functional or nonfunctional based on hormone secretion. Management of each entity is different, with nonfunctional tumors being treated with traditional chemotherapy while functional tumors respond well to antihormonal therapy and immunologic agents. The conversion of one nonfunctional tumor into a functional tumor is an exceedingly rare event that complicates the overall management of these patients. In this report, we present the case of a 73-year-old woman who developed the conversion from a nonfunctional into a functional tumor and discuss the management options considered.© 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.