Talin-1 是多蛋白粘附复合物的组成部分，在不同类型恶性肿瘤的肿瘤形成和迁移中起主要作用。本研究旨在评估卵巢浆液性癌（OSC）患者中talin-1蛋白的表达及其预后意义。利用生物信息学工具研究卵巢癌（OC）中talin-1的mRNA表达及其蛋白水平。包括基因表达谱交互分析 2 (GEPIA2)、正常和肿瘤组织基因表达数据库 2 (GENT2) 和阿拉巴马大学伯明翰分校 CANcer 数据分析门户 (UALCAN) 数据库。此后，使用免疫组织化学（IHC）染色来研究talin-1蛋白的表达模式，使用46个石蜡包埋的OSC组织标本、25个良性肿瘤和20个正常组织，将其组装在组织微阵列（TMA）中。我们还评估了talin-1蛋白的表达、各种临床病理学参数和生存结果之间的潜在关联。与良性肿瘤和正常组织相比，我们对talin-1的IHC检查在OSC组织中显着过度表达。 Kaplan-Meier 生存分析还表明，talin-1 高表达水平和低表达水平的患者在疾病特异性生存 (DSS) 和无进展生存 (PFS) 方面分别存在统计学显着差异。talin-1蛋白在 OSC 组织中过度表达，talin-1 的高表达水平被发现与肿瘤侵袭性和较差的 DSS 或 PFS 显着相关。因此，talin-1可能作为癌症进展的分子标志物和这些患者的新型预后生物标志物。

Talin-1 is a constituent of the multiprotein adhesion complexes that play main role in the formation of tumors and migration in different types of malignancies. The present study aimed to assess expression and prognostic significance of the talin-1 protein in ovarian serous carcinoma (OSC) patients.The expression of talin-1 in mRNA and its protein levels were investigated for ovarian cancer (OC) by using bioinformatics tools, including Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Gene Expression Database of Normal and Tumor Tissue 2 (GENT2), and The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN) databases. Thereafter, immunohistochemical (IHC) staining was used to study the expression patterns of the talin-1 protein using 46 paraffin-embedded OSC tissue specimens, 25 benign tumors, and 20 normal tissues, which were assembled in tissue microarrays (TMAs). We also assessed the potential association between the expression of the talin-1 protein, various clinicopathological parameters, and survival outcomes.Our IHC examination for talin-1 was significantly overexpressed in OSC tissues compared to benign tumors and normal tissues. The Kaplan-Meier survival analysis has also indicated statistically significant differences in terms of disease-specific survival (DSS) and progression-free survival (PFS) between the patients with high and low expression levels of talin-1, respectively.The talin-1 protein was overexpressed in OSC tissues, and a high expression level of talin-1 was found to be significantly associated with tumor aggressiveness and poorer DSS or PFS. Therefore, talin-1 may serve as a molecular marker of cancer progression and a novel prognostic biomarker in these patients.