目的：失巢凋亡是一种发生在正常上皮和内皮细胞中的程序性细胞死亡。然而，失巢凋亡调节因子（ANR）在膀胱癌（BLCA）中的具体作用仍不清楚。因此，本研究的目的是寻找能够识别 BLCA 不同水平失巢凋亡抵抗的亚组，并构建失巢凋亡评分系统来评估预后。方法：通过从公共数据集中获取 ANR，识别具有不同程度失巢凋亡抵抗力的 BLCA 亚群，并确定风险。结果：ANR 影响 BLCA 的发生和预后，可以通过建立风险模型进行预测。结论：失巢凋亡评分系统和失巢凋亡相关风险概况可能有助于为 BLCA 患者制定更有效和个性化的治疗策略。

Objective: Anoikis is a type of programmed cell death that occurs in normal epithelial and endothelial cells. However, the specific role of anoikis regulators (ANRs) in bladder cancer (BLCA) remains unknown. Therefore, the objective of this study was to find subgroups that could identify different levels of anoikis resistance in BLCA and construct an anoikis scoring system to assess prognosis. Method: By obtaining ANRs from public datasets, subgroups of BLCA with varying degrees of anoikis resistance were identified, and risk was determined. Result: ANRs affects the occurrence and prognosis of BLCA and can be predicted by establishing risk models. Conclusion: The anoikis scoring system and anoikis-associated risk profiles may help develop more effective and personalized treatment strategies for BLCA patients.