研究动态
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肌肉减少症对老年非霍奇金淋巴瘤患者运动治疗结果的影响。

Impact of Sarcopenia on Outcome of Exercise Therapy in Older Non-Hodgkin Lymphoma Patients.

发表日期:2023
作者: Ryuichi Kasahara, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Yuka Ohashi, Kazumi Jinbo, Yuichi Yamamoto, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Mai Owari, Shinichiro Morishita
来源: PHYSICAL THERAPY & REHABILITATION JOURNAL

摘要:

本研究的目的是调查运动疗法对接受住院化疗的老年非霍奇金淋巴瘤患者的身体功能和生活质量 (QOL) 的影响,包括患有和不患有肌肉减少症的患者之间的差异。 31 名 70 岁的住院患者岁或以上参加了这项研究。比较入院和出院时的握力和膝伸肌力量、6 分钟步行测试、身体成分、营养状况、疲劳和健康相关的生活质量。此外,将患者分为肌少症组和非肌少症组,并进行入院和出院之间的比较以及双向方差分析。总体而言,出院时的握力和骨骼肌质量显着低于入院时(P<0.01)。 05);然而,生活质量显着改善 (P < .05)。在非肌少症组中,出院时的握力、右膝伸展肌力和骨骼肌质量均显着低于入院时 (P < .05);然而,肌肉减少症组的情况并非如此。在生活质量方面,非肌肉减少症组和肌肉减少症组的不同项目均出现改善。入院至出院时间段与肌少症在左握力、右膝伸肌力和生活质量方面存在显着的交互作用。运动疗法可有效改善接受住院化疗的老年非霍奇金淋巴瘤患者的生活质量。然而,运动疗法的效果和最佳运动负荷在非肌少症患者和肌少症患者之间可能有所不同。因此,今后有必要考虑运动疗法,同时考虑是否存在肌少症。
The aim of this study was to investigate the effects of exercise therapy on physical function and quality of life (QOL) in older patients with non-Hodgkin lymphoma undergoing inpatient chemotherapy, including differences between patients with and without sarcopenia.Thirty-one inpatients aged 70 years or older participated in this study. Grip and knee extensor strength, 6-minute walking test, body composition, nutritional status, fatigue and health-related QOL at admission and discharge were compared. In addition, the patients were classified into sarcopenic and non-sarcopenic groups, and a comparison between admission and discharge and 2-way ANOVA were performed.Overall, grip strength and skeletal muscle mass were significantly lower at discharge than at admission (P < .05); however, QOL significantly improved (P < .05). In the non-sarcopenia group, grip strength, right knee extension muscle strength, and skeletal muscle mass were all significantly lower at discharge than at admission (P < .05); however, this was not the case in the sarcopenia group. In terms of QOL, improvements were observed in different items in the non-sarcopenia and sarcopenia groups. There was a significant interaction between admission to discharge time period and sarcopenia regarding left grip strength, right knee extensor strength, and QOL.Exercise therapy is effective in improving QOL in older non-Hodgkin lymphoma patients undergoing inpatient chemotherapy. However, the effect of exercise therapy and optimal exercise load may differ between non-sarcopenia and sarcopenia patients. Therefore, it is necessary to consider exercise therapy in the future, taking into account the presence or absence of sarcopenia.