流行病学证据表明，霍奇金淋巴瘤 (HL) 和多发性硬化症 (MS) 与克罗恩病 (CD) 和溃疡性结肠炎 (UC) 具有一组共同的危险因素。据推测，这种共同的危险因素将导致 4 种诊断集中在同一患者中。所有 HL、MS、CD 或 UC 患者均在 2016 年至 2020 年的退伍军人群体和 1986 年至 1989 年的医疗保险群体中被识别出来。在一项病例对照研究中，通过计算比值比 (OR) 及其 95% 置信区间 (CI)，将观察到的这 4 种诊断的同时发生率与同一时期内退伍军人或医疗保险总体人群中的预期频率进行比较。该研究包括 600 万退伍军人和 3500 万医疗保险患者。在退伍军人群体中，炎症性肠病 (IBD) 与同时诊断的 HL（OR：1.40，95% CI：1.15-1.71）和 MS（1.34，1.19-1.50）显着相关。在医疗保险人群中，IBD 也与 HL (1.84, 1.07-3.17) 和 MS (2.31, 1.59-3.35) 显着相关。当在两个数据集中单独分析时，在 CD 或 UC 中观察到类似的趋势。在退伍军人群体中，对种族、性别和年龄的潜在混杂影响进行调整后，所有 OR 值基本上未受影响且具有统计显着性。IBD 与 HL 或 MS 的并发可能反映了这 4 种疾病的病因或发病机制中的共同途径疾病。版权所有 © 2023 Wolters Kluwer Health, Inc. 保留所有权利。

Epidemiologic evidence suggests that Hodgkin lymphoma (HL) and multiple sclerosis (MS) share a common set of risk factors with Crohn's disease (CD) and ulcerative colitis (UC). It was hypothesized that such shared risk factors would lead to clustering of the 4 diagnoses in the same patients.All patients with HL, MS, CD, or UC were identified in the veterans population from 2016-2020 and the Medicare population from 1986 to 1989. In a case-control study, the observed concurrences amongst these 4 diagnoses were compared with their expected frequencies in the overall veterans or Medicare population during the same time period by calculating odds ratios (OR) with their 95% confidence intervals (CI).The study included 6 million veterans and 35 million Medicare patients. In the veterans population, inflammatory bowel disease (IBD) was significantly associated with a concurrent diagnosis of HL (OR: 1.40, 95% CI: 1.15-1.71) and MS (1.34, 1.19-1.50). In the Medicare population, IBD was also significantly associated with HL (1.84, 1.07-3.17) and MS (2.31, 1.59-3.35). Similar trends were observed in CD or UC when analyzed separately in both datasets. In the veterans population, adjustment for the potentially confounding influence of ethnicity, sex, and age left all OR values largely unaffected and statistically significant.The concurrence of IBD with HL or MS could reflect on a common pathway in the etiology or pathogenesis of these 4 diseases.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.