细胞焦亡是gasdermin介导的程序性细胞死亡（PCD）途径。它与细胞凋亡不同，因为它会分泌炎症分子。焦亡与多种恶性肿瘤密切相关。最近的研究表明，焦亡可以抑制或促进恶性肿瘤的发展，具体取决于细胞类型（免疫细胞或癌细胞）以及该过程的持续时间和严重程度。本文总结了焦亡的分子机制、其与恶性肿瘤的关系，并重点介绍了当前焦亡诱导剂及其在癌症治疗中的意义。参与焦亡信号通路的分子可以作为开发癌症治疗新药的治疗靶点。此外，我们还分析了将焦亡与传统抗癌技术相结合作为一种有前景的癌症治疗策略的潜力。© 2023。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下子公司）的独家许可。

Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell type (immune or cancer cells) and duration and severity of the process. This review summarizes the molecular mechanisms of pyroptosis, its relationship with malignancies, and focuses on current pyroptosis inducers and their significance in cancer treatment. The molecules involved in the pyroptosis signaling pathway could serve as therapeutic targets for the development of novel drugs for cancer therapy. In addition, we analyzed the potential of combining pyroptosis with conventional anticancer techniques as a promising strategy for cancer treatment.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.