旨在确定舌下腺癌的临床特征和预后因素。这是一项病例对照研究。接受手术治疗的舌下腺癌患者被回顾性纳入监测、流行病学和最终结果数据库，并分为腺样囊性癌（ACC）组和非 ACC 组。主要结果变量是疾病特异性生存期（DSS）和总生存期（OS）。使用 Cox 模型分析每组的预后因素。我们纳入了 251 名患者（115 名男性和 136 名女性）。与非ACC组相比，ACC组的平均肿瘤大小更大，接受的辅助放疗也更多。在ACC患者中，病理分级对DSS和OS有独立影响，接受辅助化疗的患者比未接受化疗的患者DSS更差。在非ACC组中，病理分级IV级、淋巴结转移和辅助化疗与较差的DSS和OS相关，肿瘤扩展预示DSS恶化。在舌下腺癌中，病理分级和辅助化疗是最重要的预后因素，而淋巴结转移对非 ACC 患者有负面影响，但对 ACC 患者没有负面影响。

To identify the clinical features and prognostic factors for sublingual gland carcinoma.This was a case-control study. Patients with surgically treated sublingual gland carcinoma were retrospectively included in the Surveillance, Epidemiology and End Results database and divided into adenoid cystic carcinoma (ACC) and non-ACC groups. Primary outcome variables were disease-specific survival (DSS) and overall survival (OS). Prognostic factors for each group were analyzed using Cox models.We included 251 patients (115 men and 136 women). Compared with the non-ACC group, the ACC group had a larger average tumor size and received more adjuvant radiotherapy. In patients with ACC, the pathologic grade had an independent impact on DSS and OS, and patients who were undergoing adjuvant chemotherapy had worse DSS than those who were not receiving chemotherapy. In the non-ACC group, pathologic grade IV, lymph node metastasis, and adjuvant chemotherapy were associated with poor DSS and OS, and tumor extension predicted worsening DSS.In sublingual gland carcinoma, the pathologic grade and adjuvant chemotherapy were the most important prognostic factors, whereas lymph node metastasis had a negative impact in non-ACC patients but not in ACC patients.