异常的核 β-连环蛋白分布不能预测子宫内膜样子宫内膜癌的复发 - 一项回顾性单机构研究。
Aberrant nuclear β-catenin distribution does not prognosticate recurrences of endometrioid endometrial cancers - A retrospective single-institutional study.
发表日期：2023 Nov 07
作者：
Isabel Beshar, Ashley S Moon, Himani Darji, Caroline Liu, Michael T Jennings, Oliver Dorigo, Babak Litkouhi, Elisabeth J Diver, Amer K Karam, Brooke E Howitt, Malte Renz
来源：
GYNECOLOGIC ONCOLOGY
摘要：
异常的 β-连环蛋白分布已被理论化为早期低级别子宫内膜样子宫内膜癌复发的预测生物标志物。这项回顾性单机构队列研究回顾了 2018 年 5 月至 2022 年 5 月期间的 410 名子宫内膜癌患者。仅包括子宫内膜样组织学。从病历中收集人口统计学和临床病理学数据。对早期、低级别和无特异性分子谱 (NSMP) 肿瘤进行单变量和多变量逻辑回归以及敏感性分析。纳入了 297 名患者进行分析。大多数患者年龄超过 60 岁，是白人，BMI > 30，患有早期低度疾病。 135 名患者 (45.5%) 发现异常 β-catenin 分布，162 名患者 (54.5%) 发现野生型膜 β-catenin 分布。虽然 TP53 突变与该队列中的子宫内膜癌复发相关 (OR = 4.78)，但异常 β-连环蛋白分布在总体人群 (OR = 0.75)、早期低级别癌症 (OR = 0.84) 或 NSMP 中不相关组（OR = 1.41）进行单变量或多变量分析。未检测到 β-catenin 分布与局部（OR = 0.61）或远处复发（OR = 0.90）之间的相关性。异常 β-catenin 分布与子宫内膜样子宫内膜癌的复发没有显着相关性，在早期、低级别和晚期子宫内膜癌中也没有显着相关性。 NSMP 子队列。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Aberrant β-catenin distribution has been theorized as a predictive biomarker for recurrence in early stage, low grade endometrioid endometrial cancer.This retrospective single-institution cohort study reviewed 410 patients with endometrial cancer from May 2018 to May 2022. Only endometrioid histology was included. Demographic and clinicopathological data were collected from the medical records. Univariate and multivariate logistic regressions, and sensitivity analyses for early stage, low grade and no specific molecular profile (NSMP) tumors were performed.297 patients were included for analysis. Most patients were over 60 years old, White, and with a BMI >30 and early stage low grade disease. Aberrant β-catenin distribution was found in 135 patients (45.5%) and wild type membranous β-catenin distribution in 162 (54.5%). While TP53 mutation correlated with endometrial cancer recurrence in this cohort (OR = 4.78), aberrant β-catenin distribution did not correlate in the overall population (OR = 0.75), the early stage low grade cancers (OR = 0.84), or the NSMP group (OR = 1.41) on univariate or multivariate analysis. No correlation between β-catenin distribution and local (OR = 0.61) or distant recurrences (OR = 0.90) was detected.Aberrant β-catenin distribution did not significantly correlate with recurrence in endometrioid endometrial cancer, nor in the early stage, low grade and NSMP sub-cohorts.Copyright © 2023 Elsevier Inc. All rights reserved.