高钠血症是一种可治疗的生化疾病，与接受手术的患者的显着发病率和死亡率相关。然而，其对接受择期开颅手术的患者的影响尚不清楚。本研究旨在探讨术后高钠血症对择期开颅手术患者30天死亡率的预后影响。回顾性队列研究。大容量中心神经外科。接受择期开颅手术的成人患者（垂体瘤、脑内肿瘤除外）出血、蛛网膜下腔出血或创伤性脑损伤。无。收集所有研究参与者的围手术期实验室数据，包括钠水平、中性粒细胞计数、血清白蛋白、淋巴细胞计数和血糖。这些测量结果是常规临床护理的一部分，为数据分析提供了有价值的信息。在 10,223 名符合纳入和排除标准的择期开颅手术患者中，14.9% (1519) 出现术后高钠血症。该人群术后 30 天的总体死亡率为 1.7% (175)。进行调整后的逻辑回归分析后，我们发现，随着高钠血症严重程度的增加，30天死亡率逐渐增加：轻度高钠血症患者死亡 2.9 例（OR，3.79；95% CI，2.46-5.85），轻度高钠血症患者死亡 13.9 例（OR，3.79；95% CI，2.46-5.85）。中度高钠血症患者中有 38.3 例死亡（OR，17.73；95% CI，11.17-28.12），重度高钠血症患者中有 38.3 例死亡（OR，67.00；95% CI，40.44-111.00）。高钠血症在择期开颅手术后很常见，并且其存在与死亡率和并发症增加有关，特别是在严重高钠血症的情况下。这些结果强调了神经外科患者风险评估的重要性，并提出了密切监测高危个体血清钠水平的优势。未来的随机对照试验可以更深入地了解这些患者术后高钠血症的治疗效果。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Hypernatremia is a treatable biochemical disorder associated with significant morbidity and mortality in patients undergoing surgery. However, its impact on patients who undergo elective craniotomy is not well understood. This study aimed to investigate the prognostic implications of postoperative hypernatremia on the 30-day mortality of patients undergoing elective craniotomy.Retrospective cohort study.The Department of Neurosurgery of a high-volume center.Adult patients undergoing elective craniotomy except those with pituitary tumors, intracerebral hemorrhage, subarachnoid hemorrhage, or traumatic brain injury.None.Perioperative laboratory data were collected for all study participants, including sodium levels, neutrophil count, serum albumin, lymphocyte count, and blood glucose. These measurements were obtained as part of routine clinical care and provided valuable information for data analysis.Of the 10,223 identified elective craniotomy patients who met our inclusion and exclusion criteria, 14.9% (1519) developed postoperative hypernatremia. This population's overall postoperative 30-day mortality rate was 1.7% (175). After performing an adjusted logistic regression analysis, we found that the odds of 30-day mortality increased gradually with increasing severity of hypernatremia: 2.9 deaths (OR, 3.79; 95% CI, 2.46-5.85) in patients with mild hypernatremia, 13.9 deaths (OR, 17.73; 95% CI, 11.17-28.12) in those with moderate hypernatremia, and 38.3 deaths (OR, 67.00; 95% CI, 40.44-111.00) in those with severe hypernatremia.Hypernatremia is common after elective craniotomy, and its presence is associated with increased mortality and complications, particularly in cases of severe hypernatremia. These results emphasize the significance of risk evaluation in neurosurgical patients and propose the advantages of closely monitoring serum sodium levels in high-risk individuals. Future randomized controlled trials could provide more insight into the effect of treating postoperative hypernatremia in these patients.Copyright © 2023 Elsevier Inc. All rights reserved.