人类肿瘤的形成和进展与新血管的异常发育（称为新血管生成）有关。血管生成是一个广泛的词，涵盖内皮细胞迁移、增殖、管形成和套叠，以及内皮细胞周围募集和细胞外基质形成。肿瘤血管生成受到血管生成因子的调节，其中一些最有效的血管生成因子，如体内的血管内皮生长因子和血管生成素（ANG）是由肿瘤微环境中的巨噬细胞和其他免疫细胞产生的。 ANG 在肿瘤血管生成和行为中具有独特的功能。 ANG1、ANG 2、ANG 3 和 ANG 4 是 ANG 家族成员，其中 ANG2 由于其在改变血管生成方面的独特作用及其与肿瘤进展、生长和侵袭/转移的密切相关性而受到广泛研究，这使得它是人类恶性肿瘤治疗干预的绝佳候选者。 ANG 调节剂在治疗肿瘤发展方面已显示出令人鼓舞的结果，无论是单独使用还是与 VEGF 抑制剂联合使用。未来需要开发更多针对其他 ANG 的 ANG 调制器。还应该评估 ANG1、ANG3 和 ANG4 作为肿瘤发展中抗血管生成治疗的可能治疗靶点的意义。本文描述了 ANG 在肿瘤血管生成和肿瘤生长中的作用，以及临床研究中证明的调节 ANG 在肿瘤血管生成中的治疗策略。应评估 ANG 的药理学调节以及负责肿瘤血管生成和癌症发展的 ANG 调节途径，以开发未来的分子疗法。版权所有 © 2023 Elsevier Inc. 保留所有权利。

The formation and progression of tumors in humans are linked to the abnormal development of new blood vessels known as neo-angiogenesis. Angiogenesis is a broad word that encompasses endothelial cell migration, proliferation, tube formation, and intussusception, as well as peri-EC recruitment and extracellular matrix formation. Tumor angiogenesis is regulated by angiogenic factors, out of which some of the most potent angiogenic factors such as vascular endothelial growth factor and Angiopoietins (ANGs) in the body are produced by macrophages and other immune cells within the tumor microenvironment. ANGs have a distinct function in tumor angiogenesis and behavior. ANG1, ANG 2, ANG 3, and ANG 4 are the family members of ANG out of which ANG2 has been extensively investigated owing to its unique role in modifying angiogenesis and its tight association with tumor progression, growth, and invasion/metastasis, which makes it an excellent candidate for therapeutic intervention in human malignancies. ANG modulators have demonstrated encouraging outcomes in the treatment of tumor development, either alone or in conjunction with VEGF inhibitors. Future development of more ANG modulators targeting other ANGs is needed. The implication of ANG1, ANG3, and ANG4 as probable therapeutic targets for anti-angiogenesis treatment in tumor development should be also evaluated. The article has described the role of ANG in tumor angiogenesis as well as tumor growth and the treatment strategies modulating ANGs in tumor angiogenesis as demonstrated in clinical studies. The pharmacological modulation of ANGs and ANG-regulated pathways that are responsible for tumor angiogenesis and cancer development should be evaluated for the development of future molecular therapies.Copyright © 2023 Elsevier Inc. All rights reserved.