大脑中的 STING 信号传导：分子威胁、信号活动和治疗挑战。
STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges.
发表日期：2023 Nov 03
作者：
Kun Yang, Zhen Tang, Cong Xing, Nan Yan
来源：
Alzheimers & Dementia
摘要：
干扰素基因刺激物 (STING) 是一种对感染、自身免疫和癌症至关重要的先天免疫信号蛋白。 STING 信号传导也正在成为许多神经系统疾病中令人兴奋且不可或缺的一部分。在这里，我们讨论大脑中 STING 信号传导的最新进展。我们总结了分子威胁如何激活患病大脑中的 STING 信号传导，以及神经胶质细胞和神经元细胞中的 STING 信号传导活动如何导致神经病理学。我们还回顾了 STING 神经生物学的人体研究，并考虑了针对 STING 治疗神经系统疾病的治疗挑战。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Stimulator of interferon genes (STING) is an innate immune signaling protein critical to infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and integral part of many neurological diseases. Here, we discuss recent advances in STING signaling in the brain. We summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology. We also review human studies of STING neurobiology and consider therapeutic challenges in targeting STING to treat neurological diseases.Copyright © 2023 Elsevier Inc. All rights reserved.