传统癌症治疗方法固有的局限性促使人们最近努力通过各种有前途的方法来设计具有高效抗癌效果的安全纳米药物。在癌症纳米药物的开发中已经引入了大量的纳米颗粒。其中，不同的脂质纳米颗粒由于许多优点和独特的机会（包括生物相容性和靶向药物输送）而受到广泛的应用。然而，为了促进癌症纳米药物开发的最新进展转化为临床实践，必须全面了解纳米生物相互作用。在这篇文章中，我们重点研究脂蛋白模拟纳米颗粒，它具有独特的特征和成分，可通过受体结合机制促进药物转运。此外，我们还描述了 siRNA 脂质纳米颗粒在未来抗癌纳米药物设计中的潜在应用。因此，本综述重点介绍了用于抗癌治疗药物靶向递送的脂质基脂蛋白模拟纳米粒子和 siRNA 纳米载体的最新进展、挑战和机遇。版权所有 © 2023。由 Elsevier B.V. 出版。

The limitations inherent in conventional cancer treatment methods have stimulated recent efforts towards the design of safe nanomedicines with high efficacy for combating cancer through various promising approaches. A plethora of nanoparticles has been introduced in the development of cancer nanomedicines. Among them, different lipid nanoparticles are attractive for use due to numerous advantages and unique opportunities, including biocompatibility and targeted drug delivery. However, a comprehensive understanding of nano-bio interactions is imperative to facilitate the translation of recent advancements in the development of cancer nanomedicines into clinical practice. In this contribution, we focus on lipoprotein-mimicking nanoparticles, which possess unique features and compositions facilitating drug transport through receptor binding mechanisms. Additionally, we describe potential applications of siRNA lipid nanoparticles in the future design of anticancer nanomedicines. Thus, this review highlights recent progress, challenges, and opportunities of lipid-based lipoprotein-mimicking nanoparticles and siRNA nanocarriers designed for the targeted delivery of anticancer therapeutic agents.Copyright © 2023. Published by Elsevier B.V.