本研究旨在调查育龄乳腺癌患者的生殖担忧，分析其影响因素，探讨应对方式、恐惧进展（FOP）与生殖担忧之间的关系，并确定应对方式对两者关系的多重影响。中国乳腺癌患者的 FOP 与生殖问题。一项横断面描述性研究于 2022 年 1 月至 2022 年 9 月在中国福建省四家三级甲等医院的乳腺癌患者中进行。总共招募了 210 名患者来完成纸质问卷，包括一般数据问卷、癌症后生殖问题量表（RCACS）、进展恐惧问卷简表（FOP-Q-SF）和医疗应对方式问卷（MCMQ）。利用结构方程模型评估应对方式对 FOP 和生殖问题的多重影响。乳腺癌患者的生殖问题平均得分为 53.02（SD，10.69），总分为 90 分，而癌症的应对方式（对抗、回避）与 FOP 和生殖问题密切相关。 FOP 与生殖问题呈显着正相关 (r=.52, p<.01)。同时，对抗与 FOP (r=-.28，p<.01) 和生殖问题 (r=-.39，p<.01) 显着负相关。回避与 FOP (r=.25, p<.01) 和生殖问题 (r=.34, p<.01) 呈正相关。对生殖问题进展的恐惧的影响部分是由对抗和回避介导的，效应大小分别为 0.07 和 0.04。这些中介因素占总效应的22.0%。FOP直接影响生殖问题，而应对方式可以部分调节FOP与生殖问题之间的关联。本研究阐明了对抗和回避在缓解生殖担忧中的作用，提示有必要关注育龄乳腺癌患者生殖担忧的变化。医疗保健专业人员可以提高疾病意识并减少患者对疾病进展的恐惧，从而促进积极的心理和应对行为，最终减轻生殖问题。版权所有 © 2023。由 Elsevier B.V. 出版。

This study aimed to investigate reproductive concerns among breast cancer patients of reproductive age, analyze the influencing factors, explore the relationship between coping styles, fear of progression (FOP), and reproductive concerns, and identify the multiple effects of coping styles on the relationship between FOP and reproductive concerns among Chinese breast cancer patients.A cross-sectional, descriptive study was conducted among breast cancer patients in four tertiary grade A hospitals in Fujian, China, from January 2022 to September 2022. A total of 210 patients were recruited to complete paper-based questionnaires, which included the general data questionnaires, the Reproductive Concerns after Cancer Scale (RCACS), the Fear of Progression Questionnaire-Short Form (FOP-Q-SF), and the Medical Coping Modes Questionnaire (MCMQ). Structural equation models were utilized to evaluate the multiple effects of coping styles on FOP and reproductive concerns.Reproductive concerns in breast cancer patients had a mean score of 53.02 (SD, 10.69), out of a total score of 90, and coping styles for cancer (confrontation, avoidance) were closely associated with FOP and reproductive concerns. FOP showed a significant positive correlation with reproductive concerns (r=.52, p<.01). At the same time, confrontation was significantly negatively correlated with both FOP (r=-.28, p<.01) and reproductive concerns (r=-.39, p<.01). Avoidance was positively correlated to both FOP (r=.25, p<.01) and reproductive concerns (r=.34, p<.01). The impact of fear of progression on reproductive concerns is partially mediated by confrontation and avoidance, with effect sizes of .07 and .04, respectively. These mediating factors account for 22.0% of the total effect.The FOP directly impacted reproductive concerns, while coping styles could partially mediate the association between FOP and reproductive concerns. This study illustrates the role of confrontation and avoidance in alleviating reproductive concerns, suggesting that it is necessary to focus on the changes in reproductive concerns among reproductive-age breast cancer patients. Healthcare professionals can improve disease awareness and reduce patients' fear of progression, thereby promoting positive psychological and coping behaviors and ultimately alleviating reproductive concerns.Copyright © 2023. Published by Elsevier B.V.