蛋白质合成失调是肿瘤的一个标志。 mRNA 翻译重编程有助于肿瘤发生，而肿瘤发生是由核糖体形成、tRNA 丰度和修饰以及翻译因子的异常加剧的。在翻译重编程过程中，不仅恶性细胞而且肿瘤微环境中的基质细胞也可以向致瘤表型转化。核糖体失活蛋白（RIP）因其选择性抑制蛋白质合成和抑制肿瘤生长的能力而引起人们的兴趣。本综述总结了失调的翻译机制在肿瘤发展中的作用，并探讨了 RIP 在癌症治疗中的潜力。版权所有 © 2023。由 Elsevier B.V. 出版。

Dysregulated protein synthesis is a hallmark of tumors. mRNA translation reprogramming contributes to tumorigenesis, which is fueled by abnormalities in ribosome formation, tRNA abundance and modification, and translation factors. Not only malignant cells but also stromal cells within tumor microenvironment can undergo transformation toward tumorigenic phenotypes during translational reprogramming. Ribosome-inactivating proteins (RIPs) have garnered interests for their ability to selectively inhibit protein synthesis and suppress tumor growth. This review summarizes the role of dysregulated translation machinery in tumor development and explores the potential of RIPs in cancer treatment.Copyright © 2023. Published by Elsevier B.V.