本工作从理论上检验了带缺陷的一维光子晶体的超高灵敏度癌细胞检测能力。利用MATLAB编程和传递矩阵法对工作进行了仿真。通过改变周期数、缺陷层厚度和与 s 偏振光相对应的入射角，研究了分别加载含有不同癌细胞的样品的所提出的生物传感器的性能，以确定所提出的设计变得超灵敏的参数。所提出的生物传感器的工作原理是感测含有不同人类癌细胞的分析物的折射率的微小变化。由于所考虑的样品的折射率的变化，这种感测是通过将结构的光子带隙内的相应缺陷模式从一个位置移动到附近的另一个位置来完成的。我们的结构在最佳条件下产生从 1538 nm 到 1648 nm 的缺陷模式位置的最大偏移，对应于包含折射率分别为 1.350 和 1.4470 的正常细胞和胶质母细胞瘤细胞的样品，从而产生 4270.525928 nm/RIU 的超高灵敏度。© 2023 . 作者。

The ultra-high sensitive cancer cell detection capabilities of one-dimensional photonic crystal with defect have been theoretically examined in this work. The simulations of the work have been carried out with MATLAB programming and transfer matrix method. The performance of the proposed biosensor loaded separately with samples containing different cancer cells has been studied by changing the period number, defect layer thickness, and incident angle corresponding to s polarized light only to identify the parameters under which the proposed design becomes ultra-sensitive. The working principle of the proposed biosensor is to sense the minute change in the refractive index of the analytes containing different cancer cells of human. This sensing is done shifting the respective defect mode inside photonic band gap of the structure from one position to other near by position due to change in the refractive index of sample under consideration. Our structure under optimum conditions yields maximum shifting in the position of defect mode from 1538 to 1648 nm corresponding to the samples containing normal and Glioblastoma cells of refractive indices 1.350 and 1.4470 respectively which results a ultra-high sensitivity of 4270.525928 nm/RIU.© 2023. The Author(s).