用于癌症治疗中药物输送的细胞外囊泡。
Extracellular Vesicles for Drug Delivery in Cancer Treatment.
发表日期:2023 Nov 09
作者:
Li Wang, Xin Yu, Juan Zhou, Chunxia Su
来源:
BIOLOGICAL PROCEDURES ONLINE
摘要:
细胞外囊泡(EV)是源自细胞的纳米级囊泡,通过运输生物活性分子来介导细胞间通讯。它们在各种生理和病理条件下发挥着重要作用。 EV 作为疾病的新型生物标志物、治疗剂和药物输送工具具有巨大的潜力。此外,电动汽车作为新型药物输送工具在临床前环境中表现出显着的优势。在这篇综述中,我们讨论了 EV 的生物发生和特征及其在癌症中的功能。我们总结了 EV 作为天然递送载体在癌症治疗中的治疗应用。我们强调现有的挑战,阐明重要问题,并提出有效解决这些问题的建议。© 2023。作者。
Extracellular vesicles (EVs) are nanoscale vesicles derived from cells that mediate intercellular communication by transporting bioactive molecules. They play significant roles in various physiological and pathological conditions. EVs hold great potential as novel biomarkers of diseases, therapeutic agents, and drug delivery vehicles. Furthermore, EVs as novel drug delivery vehicles have demonstrated significant advantages in preclinical settings. In this review, we discussed the biogenesis and characteristics of EVs and their functions in cancer. We summarize the therapeutic applications of EVs as a natural delivery vehicles in cancer therapy. We highlight the existing challenges, illuminate vital questions, and propose recommendations to effectively address them effectively.© 2023. The Author(s).