基于核酸适体的纳米胶束在纳米医学和纳米技术应用方面具有巨大的潜力。然而，已知两亲性适体胶束在生理环境中与细胞膜相互作用时本质上不稳定，因此可能损害其针对癌细胞的特异性靶向。目前的工作解决了这个缺陷，该工作报告了一种超稳定的胶束纳米递送系统，该系统是由核酸适体和多价疏水性聚（马来酸酐-alt-1-十八碳烯）（C18PMH）组成的两亲性共聚物自组装胶束。使用Ce6作为药物模型，这些C18适体胶束表现出高效的肿瘤靶向和结合能力，促进Ce6进入靶向细胞进行光动力治疗。此外，它们可以负载其他疏水性药物，仍然表现出良好的治疗效果。因此，这些 C18-适体胶束可以作为装载多种药物的通用平台，为治疗癌症提供更安全、更有效的解决方案。© 2023。作者。

Nucleic acid aptamer-based nanomicelles have great potential for nanomedicine and nanotechnology applications. However, amphiphilic aptamer micelles are known to be inherently unstable upon interaction with cell membranes in the physiological environment, thus potentially compromising their specific targeting against cancer cells. This flaw is addressed in the present work which reports a superstable micellar nanodelivery system as an amphiphilic copolymer self-assembled micelle composed of nucleic acid aptamer and polyvalent hydrophobic poly(maleic anhydride-alt-1-octadecene) (C18PMH). Using Ce6 as a drug model, these C18-aptamer micelles exhibit efficient tumor-targeting and -binding ability, facilitating the entry of Ce6 into targeted cells for photodynamic therapy. In addition, they can be loaded with other hydrophobic drugs and still demonstrate favorable therapeutic effects. As such, these C18-aptamer micelles can serve as a universal platform for loading multiple drugs, providing a safer and more effective solution for treating cancer.© 2023. The Author(s).