计算机断层扫描 (CT) 和数字减影血管造影 (DSA) 等各种 X 射线成像技术广泛用于治疗肝细胞癌 (HCC) 患者的经导管动脉栓塞 (TAE) 疗法。尽管它们显示高对比度成像，但它们也有一些缺点，例如操作复杂和暴露于电离辐射。因此，超声（US）成像因其操作简单快速、无电离辐射暴露、实时成像准确等优点，在医学诊断中发挥着重要作用。随后，合成了聚N-异丙基丙烯酰胺-co-2,2,3,4,4,4-甲基丙烯酸六氟丁酯(PNF)纳米凝胶，用于稳定TGFPE、2H,3H-十氟戊烷(HDFP)的Pickering乳液。这些乳液显示出热敏溶胶-凝胶转变和体外长期超声成像的双重能力。因此，根据 TAE 动物模型结果得出结论，这些乳液可以实现血管栓塞和体内长期超声成像。在美国成像引导下，乳液液滴的流动和积累被可视化。总之，Pickering 乳剂有潜力用作超声引导的栓塞材料，用于介导 TAE 手术。© 2023。作者。

Various X-ray imaging technologies like computed tomography (CT) and digital subtraction angiography (DSA) are widely used in transcatheter arterial embolization (TAE) therapy for treating hepatocellular cancer (HCC) patients. Although they display high-contrast imaging, they have a few disadvantages, such as complex operation and exposure to ionizing radiation. Thus, ultrasound (US) imaging plays an important role in medical diagnosis because of its advantages, like simple and fast operation, no ionizing radiation exposure, and accurate real-time imaging. Subsequently, Poly N-isopropylacrylamide-co-2,2,3,4,4,4-Hexafluorobutyl methacrylate (PNF) nanogels were synthesized for stabilizing TGFPE, the Pickering emulsions of 2H, 3H-decafluoropentane (HDFP). These emulsions displayed dual abilities of thermosensitive sol-gel transition and long-term US imaging in vitro. Thus, it was concluded that these emulsions could achieve vascular embolization and long-term US imaging in vivo as per the TAE animal model results. The emulsion droplets' flow and accumulation were visualized under the US imaging guidance. In summary, the Pickering emulsions have the potential to be used as US-guided embolization material for mediating TAE surgeries.© 2023. The Author(s).