研究动态
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墨西哥火鸡尾药用蘑菇(花斑栓菌、伞形孢菌)提取物对人类淋巴细胞培养物的有丝分裂和基因毒性作用的检测。

Detection of Mitogenic and Genotoxic Effects of the Turkey Tail Medicinal Mushroom (Trametes versicolor, Agaricomycetes) Extracts from Mexico on Human Lymphocyte Cultures.

发表日期:2023
作者: Letzi de Jesus Salinas-Solis, Juan Carlos Gaytan-Oyarzun, Pablo Octavio-Aguilar
来源: Parasites & Vectors

摘要:

由免疫系统受损引起的疾病(例如免疫缺陷或慢性感染)正变得越来越突出,其特征是 T 淋巴细胞的产生和多样化减少。这些疾病导致更容易受到寄生虫、病毒、细菌、真菌和其他微生物引起的感染。根据各种文章,花斑栓菌因其多糖而被用于免疫疗法和癌症治疗,这在传统医学中显示了其价值。然而,大多数研究都是针对亚洲样本进行的。因此,本研究的目的是评估墨西哥花斑变色龙样本对人类淋巴细胞的影响。在各种提取物中,具有最佳 T 细胞增殖反应的提取物是在室温下在水中浸渍产生的提取物,但所有水提取物和乙醇提取物的处理都增加了淋巴细胞计数,表明墨西哥 T. versicolor 提取物还含有以下化合物:刺激T细胞。不幸的是,已发现以微核计数增加表示的遗传损伤,因此在传统医学中使用这些真菌提取物需要仔细控制推荐剂量。
Diseases caused by a compromised immune system, characterized by decreased production and diversification of T lymphocytes, such as immunodeficiencies or chronic infections, are becoming increasingly prominent. These diseases lead to increased vulnerability to infections caused by parasites, viruses, bacteria, fungi, and other microorganisms. According to various articles, Trametes versicolor has been used as immunotherapy and cancer treatment due to its polysaccharides, which have shown their value in traditional medicine. However, most of the studies have been done with Asian samples. For this reason, the aim of this study was to evaluate the effect of samples of Mexican T. versicolor on human lymphoid cells. Of various extracts, the one with the best T cell proliferative response was the extract produced by maceration in water at room temperature, but all treatments in aqueous and ethanolic extracts increased the lymphocyte count, showing that extracts of Mexican T. versicolor also have compounds that stimulate T cells. Unfortunately, genetic damage expressed as an increment in micronuclei count was identified, so using these fungus extracts in traditional medicine would require careful control of recommended doses.