尽管有大量证据表明酒精、烟草和 HPV 感染与口咽部的致癌影响有关，但吸入性工作场所危害的影响仍然不明确。我们的目的是确定文献是否揭示职业环境患口咽癌 (OPC) 的风险高于平均水平，并总结现有数据。为了确定评估职业暴露与 OPC 风险之间关系的研究，通过 PubMed-NCBI 数据库进行了文献检索，最终选择了 15 篇符合资格标准的原创文章。仅包含关注职业暴露与特定 OPC 风险或死亡之间关联的英文原创文章。现有数据表明，服务员、厨师和管家、艺术工作者、家禽和肉类工人、机械师以及接触灰尘的世贸中心急救人员感染 OPC 的风险可能会增加。然而，有关职业相关 OPC 的现有文献有限。为了确定面临风险的职业类别，需要进行大量的长期随访。识别与职业相关因素的因果关系需要对混杂因素进行充分调整的剂量反应分析。

While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose-response analyses adequately adjusted for confounders.