如果口咽部高危 HPV 感染没有被免疫系统消除并持续多年，可能会导致口咽部癌症的发展。 HPV 感染在生殖器区域非常常见，并且可以作为 HPV 储存库。在这项研究中，我们调查了生殖器 HPV 感染的女性是否有更高的风险通过生殖器-口咽传播而携带未检测到的口咽 HPV 感染。这项研究纳入了进行常规妇科检查的女性。所有参与者都接受了生殖器区域和口咽部的 HPV 刷检。此外，还通过结构化问卷评估了 HPV 感染的可能危险因素。本研究纳入了 142 名女性。口咽部 HPV 感染率较低，2/142 (1.4%) 女性的低危 HPV 基因型呈阳性。在生殖器刷检中，54/142 (38%) 女性的 HPV 检测结果呈阳性，其中 41/142 (29%) 的女性高危 HPV 基因型呈阳性。 2/142 女性患有低风险 HPV 感染。© 2023。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

If not eliminated by the immune system and persisting over years, oropharyngeal high-risk HPV infection can lead to cancer development in the oropharynx. HPV infection is very commonly found in the genital region and can serve as an HPV reservoir. In this study, we investigate whether women with a genital HPV infection are at a higher risk of harboring an undetected oropharyngeal HPV infection via genital-oropharyngeal transmission.Women presenting for routine gynecological checkups were included in this study. All participants received an HPV brush test from the genital region as well as from the oropharynx. Additionally, probable risk factors for an HPV infection were assessed in a structured questionnaire.142 women were included in this study. The rate of oropharyngeal HPV infection was low with 2/142 (1,4%) women positive for a low-risk HPV genotype. In the genital brush test, 54/142 (38%) women were tested HPV positive of which 41/142 (29%) were positive for a high-risk HPV genotype.The rate of an oropharyngeal HPV detection in our population was low with 2/142 women harboring a low-risk HPV infection.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.