大多数调查身体活动与骨质疏松症预防之间关系的研究仅关注特定类型的身体活动。这项研究关于睡眠持续时间和体力活动的综合影响或相互作用的证据。研究结果强调了睡眠时间和体力活动与骨质疏松症相关的作用。这项横断面研究研究了台湾成年人体力活动、睡眠时间和骨质疏松症患病率之间的关系。台湾生物银行招募了一个基于社区的队列约 120,000 名志愿者（截至 2020 年 4 月 30 日），年龄在 30 至 76 岁之间，无癌症病史。其中，通过双能 X 射线吸收测定法 (DXA) 测量了 22,402 名参与者的骨矿物质密度 (BMD)。排除没有 BMI (n = 23)、MET 评分 (n = 207)、T 评分 (n = 8,826) 和睡眠时间 (n = 16) 完整数据的个体后，13,330 名受试者被纳入主要队列。通过单变量和多变量回归分析来确定骨质疏松症的存在、体力活动水平、睡眠时间和其他变量之间的关联。结果显示，调整后，体力活动量 < 20 METs/周和 ≥ 20 METs/周的受试者与 MET 为零的人相比，（aOR = 1.017 和 0.767）与骨质疏松症风险相关。每天睡眠时间 ≥ 8小时的受试者患骨质疏松症的几率并没有显着降低（aOR = 0.934，p=0.266）。此外，与没有体力活动的短睡眠者相比，每周增加体力活动 ≥20 METs且睡眠时间≥ 8小时/天的成年人患骨质疏松症的可能性显着最低（aOR = 0.702）。中等体力活动（< 20 METs/周）加上平均睡眠时间（6.5-8 小时/天）的人患骨质疏松症的几率并没有显着升高（aOR = 1.129，p=0.151）。研究结果强调了睡眠的联合作用与骨质疏松症相关的持续时间和体力活动。体力活动多且睡眠时间长的成年人的 BMD 最高，骨质疏松症风险最低。© 2023。作者。

Most studies investigating the association between physical activity and osteoporosis prevention only focused on specific types of physical activity. This study's evidence regarding the combined effects or interaction of sleep duration and physical activity. The findings emphasize the role of sleep duration and physical activity in association with osteoporosis.The associations between physical activity, sleep duration, and prevalent osteoporosis in Taiwanese adults were studied in this cross-sectional study.The Taiwan Biobank enrolled a community-based cohort of ~ 120,000 volunteers (as of April 30, 2020) between 30 and 76 years of age with no history of cancer. Amongst, bone mineral density (BMD) measures by dual-energy X-ray absorptiometry (DXA) were available in 22,402 participants. After excluding individuals who had no complete data of BMI (n = 23), MET score (n = 207), T-score (n = 8,826), and sleep duration (n = 16), 13,330 subjects were included as the primary cohort. Univariate and multivariable regression analyses were performed to determine the associations between the presence of osteoporosis, physical activity level, sleep duration, and other variables.The results showed that after adjustment, subjects with physical activity < 20 METs/week and ≥ 20 METs/week (aOR = 1.017 and 0.767, respectively) were associated with risk of osteoporosis than those with zero MET. The odds of osteoporosis were not significantly lower in subjects who slept for ≥ 8 h/day (aOR = 0.934,p=0.266). In addition, compared to short sleepers with no physical activity, adults with increased physical activity ≥ 20 METs/week and sleep ≥ 8 h/day had a significantly lowest likelihood of osteoporosis (aOR = 0.702). Those with medium physical activity (< 20 METs/week) plus average sleep duration (6.5-8 h/day) did not have significant higher odds of osteoporosis (aOR = 1.129,p=0.151).The findings emphasize the joint role of sleep duration and physical activity in association with osteoporosis. Adults with high physical activity plus high sleep hours have the highest BMD and lowest risk of osteoporosis.© 2023. The Author(s).