接受开颅手术的脑肿瘤患者与静脉血栓栓塞（VTE）的发生显着相关，但其影响因素仍存在争议。我们的研究旨在调查脑肿瘤术后患者 VTE 的患病率和危险因素。我们检索了 PubMed、Embase、Web of Science、Medline 和 Cochrane Library 数据库，从建库到 2023 年 7 月。文章选择、数据提取和研究质量评估由两名评审员独立进行。使用 Egger 和 Begg 测试评估发表偏倚。使用Stata 15.0软件进行数据分析。总共考虑了25项研究，总共49,620名脑肿瘤个体。脑肿瘤术后患者住院期间 VTE 的汇总患病率为 9% [95% CI: (0.08, 0.10)]。此外，我们的结果表明，患有 VTE 的患者比未患 VTE 的患者年龄更大 [平均差 [MD] = 8.14, 95% CI: (4.97, 11.30)]。以下变量与 VTE 显着相关：既往 VTE 病史 [OR = 7.81，95% CI：(3.62，16.88)]、充血性心力衰竭 [OR = 2.33，95% CI：(1.08-5.05)]、糖尿病 [ OR = 1.87, 95% CI: (1.12-3.10)]、高血压 [OR = 1.27, 95% CI: (1.07-1.50)]、类固醇使用 [OR = 1.63, 95% CI: (1.41, 1.88)]、高白细胞计数 [MD = 0.32, 95% CI: (0.01, 0.63)] 和高纤维蛋白原水平 [MD = 0.19, 95% CI: (0.08, 0.30)]。这项荟萃分析确定了术后的危险因素脑肿瘤患者的 VTE，可为医务人员处理和治疗 VTE 提供理论基础。CRD42023357459.© 2023. Fondazione Società Italiana di Neurologia。

Brain tumor patients undergoing craniotomy are significantly associated with the development of venous thromboembolism (VTE), while the contributing factors remains controversial. Our study aimed to investigate the prevalence and risk factors for VTE in postoperational brain tumor patients.We searched the PubMed, Embase, Web of Science, Medline, and Cochrane Library databases from their inception to July 2023. Article selection, data extraction, and study quality assessment were performed independently by two reviewers. Publication bias was assessed using Egger's and Begg's tests. Stata 15.0 software was used for data analysis.A total of 25 studies were considered, with a total of 49,620 brain tumor individuals. The pooled prevalence of VTE during hospitalization in postoperational brain tumor patients was 9% [95% CI: (0.08, 0.10)]. Moreover, our results demonstrated that patients with VTE were older than those without VTE [mean difference [MD] = 8.14, 95% CI: (4.97, 11.30)]. The following variables were significantly associated with VTE: prior history of VTE [OR = 7.81, 95% CI: (3.62, 16.88)], congestive heart failure [OR = 2.33, 95% CI: (1.08-5.05)], diabetes [OR = 1.87, 95% CI: (1.12-3.10)], hypertension [OR = 1.27, 95% CI: (1.07-1.50)], steroid use [OR = 1.63, 95% CI: (1.41, 1.88)], high white blood cells counts [MD = 0.32, 95% CI: (0.01, 0.63)], and high fibrinogen levels [MD = 0.19, 95% CI: (0.08, 0.30)].This meta-analysis identified risk factors for postoperational VTE in patients with brain tumor, which can serve as a theoretical foundation for medical staff to manage and treat VTE.CRD42023357459.© 2023. Fondazione Società Italiana di Neurologia.