与其他种族群体相比，美国黑人中风和中风相关死亡的年龄更小且更频繁。缺乏研究人际种族主义与中风的前瞻性关联。为了研究美国黑人女性中感知到的人际种族主义与中风事件的关联。黑人女性健康研究是一项针对美国各地 59000 名黑人女性的前瞻性队列研究，评估了感知到的人际种族主义与中风发病率之间的纵向关联。无中风的参与者从 1997 年开始接受随访，直至中风发作、死亡、失访或研究期结束（2019 年 12 月 31 日）。 Cox 模型用于估计风险比 (HR) 和 95% CI，并调整主要混杂因素，包括教育、社区社会经济环境和心脏代谢因素。数据分析的时间为 2021 年 3 月至 2022 年 12 月。在 1997 年完成的调查问卷中，参与者报告了日常生活中以及在处理涉及就业、住房和与警察互动的情况时遭受种族主义的经历。中风是通过自我报告确定的每两年一次的调查问卷、医疗记录裁决以及与国家死亡指数的联系。 1997 年，48375 名黑人妇女（平均 [SD] 年龄，41 [10] 岁）提供了有关感知到的人际种族主义的信息，并且没有心血管疾病和癌症。在 22 年的跟踪调查中，共发现了 1664 例中风病例；其中，550例为经神经科医生审查和/或国家死亡指数联动确认的确诊病例。在就业、住房和与警察互动这 3 个领域中报告的种族主义经历与没有此类经历的多变量 HR 分别为 1.38 (95% CI, 1.14-1.67)，对于所有事件案件增加了 38%，对于所有事件案件，增加了 1.37 (95% CI)。 CI，1.00-1.88）对于确定的情况。为了比较日常人际种族主义得分最高四分位的女性与最低四分位的女性，包含所有中风事件的分析，多变量 HR 为 1.14（95% CI，0.97-1.35），多变量 HR 为 1.09（95% CI，0.83-1.45）。 ）用于仅包括明确案例的分析。在这项研究中，报告在涉及就业、住房和与警察互动的情况下经历过人际种族主义的黑人女性似乎有更高的中风风险，即使考虑了人口和血管危险因素，表明美国黑人女性所经历的种族主义的沉重负担可能会导致中风发病率的种族差异。

Black individuals in the US experience stroke and stroke-related mortality at younger ages and more frequently than other racial groups. Studies examining the prospective association of interpersonal racism with stroke are lacking.To examine the association of perceived interpersonal racism with incident stroke among US Black women.The Black Women's Health Study, a prospective cohort study of 59 000 Black women from across the US, assessed the longitudinal association between perceived interpersonal racism and stroke incidence. Stroke-free participants were followed up from 1997 until onset of stroke, death, loss to follow-up, or the end of the study period (December 31, 2019). Cox models were used to estimate hazard ratios (HRs) and 95% CIs, adjusting for major confounders, including education, neighborhood socioeconomic environment, and cardiometabolic factors. Data analysis was performed from March 2021 until December 2022.On a questionnaire completed in 1997, participants reported experiences of racism in everyday life and when dealing with situations that involved employment, housing, and interactions with police.Strokes were identified through self-report on biennial questionnaires, medical records adjudication, and linkage with the National Death Index.In 1997, 48 375 Black women (mean [SD] age, 41 [10] years) provided information on perceived interpersonal racism and were free of cardiovascular disease and cancer. During the 22 years of follow-up, 1664 incident stroke cases were identified; among them, 550 were definite cases confirmed by neurologist review and/or National Death Index linkage. Multivariable HRs for reported experiences of racism in all 3 domains of employment, housing, and interactions with police vs no such experiences were 1.38 (95% CI, 1.14-1.67), a 38% increase, for all incident cases and 1.37 (95% CI, 1.00-1.88) for definite cases. For comparisons of women in the highest quartile of everyday interpersonal racism score vs women in the lowest quartile, multivariable HRs were 1.14 (95% CI, 0.97-1.35) for analyses that included all incident stroke and 1.09 (95% CI, 0.83-1.45) for analyses that included definite cases only.In this study, Black women who reported experiences of interpersonal racism in situations involving employment, housing, and interactions with police appeared to have an increased risk of stroke, even after accounting for demographic and vascular risk factors, suggesting that the high burden of racism experienced by Black US women may contribute to racial disparities in stroke incidence.