治疗时间间隔的延迟与口腔鳞状细胞癌（OCSCC）的总生存期相关。本研究的目的是找出导致治疗间隔延长的瓶颈。对接受手术和辅助放射治疗的 OCSCC 患者队列进行回顾性分析。感兴趣的终点是延长治疗间隔。使用多变量逻辑回归来调整患者和肿瘤特征。中位诊断到治疗间隔 (DTI) 和手术到开始术后放射治疗间隔 (S-PORT) 分别为 39 天 (IQR 30-54) 和 64 天 (IQR 30-54) IQR 54-66），分别。延长的 DTI 与年龄较大、查尔森合并症指数评分较差和 T 分期较差有关。 DTI 延长的患者获得术前影像报告的时间较长（25 天与 9 天；P < 0.01）。术前病理检查的时间没有差异。延长 S-PORT 时间与病理报告时间较长（28 天与 18 天；P < 0.01）、颌面会诊时间（38 天与 15 天；P < 0.01）以及颌面放射批准时间（50 天与 28 天；P < 0.01）相关。 0.01）。在需要肿瘤内科会诊的患者中，S-PORT 时间较长的患者等待会诊的时间较长（58 天 vs 38 天；P = 0.02）。多变量分析显示 DTI 延长的独立预测因素：术前成像时间；和延长 S-PORT：病理报告时间、颌面会诊时间和肿瘤内科会诊时间。针对这些组织瓶颈的策略可能有效缩短治疗时间间隔，从而代表改善 OCSCC 患者肿瘤结果的潜在机会。版权© 2023 Elsevier Ltd. 保留所有权利。

Delays in treatment time intervals have been associated with overall survival in oral cavity squamous cell carcinoma (OCSCC). The aim of this study was to identify bottlenecks leading to prolonged treatment intervals.A retrospective analysis was conducted using a cohort of OCSCC patients who underwent surgery and adjuvant radiation therapy. The endpoints of interest were prolonged treatment intervals. Multivariable logistic regression was used to adjust for patient and tumour characteristics.Median diagnosis-to-treatment interval (DTI) and surgery to initiation of postoperative radiation therapy interval (S-PORT) were 39 days (IQR 30-54) and 64 days (IQR 54-66), respectively. Prolonged DTI was associated with older age, worse Charlson Comorbidity index scores and worse T stages. Patients with prolonged DTI had longer times to preoperative imaging reports (25 vs 9 days; P < 0.01). Time to preoperative pathology did not differ. Prolonged S-PORT was associated with longer times to pathology report (28 vs 18 days; P < 0.01), to maxillofacial consult (38 vs 15 days; P < 0.01) and to maxillofacial approval of radiation (50 vs 28 days; P < 0.01). In patients requiring medical oncology consults, those with prolonged S-PORT had longer waiting times until consultation (58 vs 38 days; P = 0.02). Multivariate analysis showed independent predictors of prolonged DTI: time to preoperative imaging; and prolonged S-PORT: time to pathology report, time to maxillofacial consult, and time to medical oncology consult.Strategies targeting these organizational bottlenecks may be effective for shortening treatment time intervals, hence representing potential opportunities for improving oncological outcomes in OCSCC patients.Copyright © 2023 Elsevier Ltd. All rights reserved.